Gene Ontology

Gene Info

• Species:Human (Homo sapiens)
• GeneID:5664
• Symbol:PSEN2
• Description:presenilin 2

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
5664	GO:0000776	IDA	located_in	kinetochore	9298903	Component
5664	GO:0005637	IDA	located_in	nuclear inner membrane	9298903	Component
5664	GO:0005783	IDA	located_in	endoplasmic reticulum	15274632	Component
5664	GO:0005794	IDA	located_in	Golgi apparatus	15274632	Component
5664	GO:0005813	IDA	located_in	centrosome	9298903	Component
5664	GO:0005886	IDA	located_in	plasma membrane	15274632	Component
5664	GO:0016020	HDA	located_in	membrane	19946888	Component
5664	GO:0032991	IDA	part_of	protein-containing complex	9632714	Component
5664	GO:0070765	IDA	part_of	gamma-secretase complex	12297508	Component

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
5664	GO:0005515	IPI	enables	protein binding	9223340,10366599,10748169,12297508,21163940,32814053.....	Function

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
5664	GO:0006509	IDA	involved_in	membrane protein ectodomain proteolysis	15274632	Process
5664	GO:0016485	IDA	involved_in	protein processing	15274632,27608597	Process
5664	GO:0034205	IDA	involved_in	amyloid-beta formation	27608597	Process
5664	GO:0042987	IDA	involved_in	amyloid precursor protein catabolic process	27608597	Process
5664	GO:0043085	IDA	involved_in	positive regulation of catalytic activity	15274632	Process
5664	GO:0110097	IMP	involved_in	regulation of calcium import into the mitochondrion	21285369	Process
5664	GO:1990456	IMP	involved_in	mitochondrion-endoplasmic reticulum membrane tethering	21285369	Process