Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:57154
  • Symbol:SMURF1
  • Description:SMAD specific E3 ubiquitin protein ligase 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
57154 GO:0000209 IDA involved_in protein polyubiquitination 19937093 Process
57154 GO:0006511 IDA involved_in ubiquitin-dependent protein catabolic process 10458166,11278251,12151385,19937093 Process
57154 GO:0006611 IDA involved_in protein export from nucleus 11278251 Process
57154 GO:0016567 IDA involved_in protein ubiquitination 11278251 Process
57154 GO:0030154 IDA involved_in cell differentiation 10458166 Process
57154 GO:0030509 IDA involved_in BMP signaling pathway 21572392 Process
57154 GO:0030512 IDA involved_in negative regulation of transforming growth factor beta receptor signaling pathway 11278251,12151385 Process
57154 GO:0030514 IDA involved_in negative regulation of BMP signaling pathway 27214554 Process
57154 GO:0032801 IDA involved_in receptor catabolic process 12151385 Process
57154 GO:0034394 IDA involved_in protein localization to cell surface 12151385 Process
57154 GO:0043161 IDA involved_in proteasome-mediated ubiquitin-dependent protein catabolic process 11278251 Process
57154 GO:0061736 IMP involved_in engulfment of target by autophagosome 22020285 Process
57154 GO:0061753 IMP involved_in substrate localization to autophagosome 22020285 Process
57154 GO:0071211 IMP involved_in protein targeting to vacuole involved in autophagy 22020285 Process
57154 GO:1903861 IDA involved_in positive regulation of dendrite extension 23999003 Process
57154 GO:2000060 IMP involved_in positive regulation of ubiquitin-dependent protein catabolic process 21454619 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
57154 GO:0004842 IDA enables ubiquitin-protein transferase activity 10458166,19937093 Function
57154 GO:0005515 IPI enables protein binding 15231748,19914168,19937093,20580715,21382345,21572392,22020285..... Function
57154 GO:0061630 IDA enables ubiquitin protein ligase activity 11278251,12151385 Function
57154 GO:0070411 IPI enables I-SMAD binding 11278251,12151385 Function
57154 GO:0070412 IPI enables R-SMAD binding 11278251 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
57154 GO:0005737 IDA located_in cytoplasm 11278251,12151385,21572392 Component
57154 GO:0005739 IGI colocalizes_with mitochondrion 22020285 Component
57154 GO:0005886 IDA located_in plasma membrane 12151385 Component
57154 GO:0070062 HDA located_in extracellular exosome 19056867 Component