Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:5747
  • Symbol:PTK2
  • Description:protein tyrosine kinase 2

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5747 GO:0001725 IDA located_in stress fiber 24036928 Component
5747 GO:0005634 IDA located_in nucleus 15855171 Component
5747 GO:0005737 IDA located_in cytoplasm Component
5747 GO:0005829 IDA located_in cytosol 15855171 Component
5747 GO:0005886 IDA located_in plasma membrane Component
5747 GO:0005925 IDA located_in focal adhesion 10655584,15855171,23574715 Component
5747 GO:0036064 IDA located_in ciliary basal body 31630787 Component
5747 GO:0043231 IDA located_in intracellular membrane-bounded organelle Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5747 GO:0001932 IGI involved_in regulation of protein phosphorylation 19913511 Process
5747 GO:0001934 IMP involved_in positive regulation of protein phosphorylation 15166238 Process
5747 GO:0007179 IDA involved_in transforming growth factor beta receptor signaling pathway 24036928 Process
5747 GO:0007229 IDA involved_in integrin-mediated signaling pathway 24036928 Process
5747 GO:0007229 IMP involved_in integrin-mediated signaling pathway 11331870 Process
5747 GO:0008360 IMP involved_in regulation of cell shape 10655584,15166238 Process
5747 GO:0010632 IGI involved_in regulation of epithelial cell migration 19913511 Process
5747 GO:0010634 IGI involved_in positive regulation of epithelial cell migration 26944318 Process
5747 GO:0010718 IGI involved_in positive regulation of epithelial to mesenchymal transition 26944318 Process
5747 GO:0010759 IGI acts_upstream_of positive regulation of macrophage chemotaxis 26754294 Process
5747 GO:0010763 IDA involved_in positive regulation of fibroblast migration 26763945 Process
5747 GO:0014068 IMP involved_in positive regulation of phosphatidylinositol 3-kinase signaling 15166238 Process
5747 GO:0016477 IMP involved_in cell migration 20305651,26934001 Process
5747 GO:0018108 IDA involved_in peptidyl-tyrosine phosphorylation 10655584,11331870 Process
5747 GO:0022408 IDA involved_in negative regulation of cell-cell adhesion 21703394 Process
5747 GO:0030335 IDA involved_in positive regulation of cell migration 11331870,21703394 Process
5747 GO:0033628 IDA involved_in regulation of cell adhesion mediated by integrin 10655584 Process
5747 GO:0042127 IMP involved_in regulation of cell population proliferation 18206965 Process
5747 GO:0043066 IMP involved_in negative regulation of apoptotic process 15166238 Process
5747 GO:0045667 IMP involved_in regulation of osteoblast differentiation 16927379 Process
5747 GO:0045860 IMP involved_in positive regulation of protein kinase activity 11331870 Process
5747 GO:0046777 IDA involved_in protein autophosphorylation 10655584,11331870 Process
5747 GO:0048013 IDA involved_in ephrin receptor signaling pathway 10655584 Process
5747 GO:0051893 IGI involved_in regulation of focal adhesion assembly 19913511 Process
5747 GO:0051897 IGI involved_in positive regulation of protein kinase B signaling 26944318 Process
5747 GO:0051897 IMP involved_in positive regulation of protein kinase B signaling 15166238 Process
5747 GO:0060396 IDA involved_in growth hormone receptor signaling pathway 10925297 Process
5747 GO:0090303 IDA involved_in positive regulation of wound healing 26763945 Process
5747 GO:0120041 IGI acts_upstream_of positive regulation of macrophage proliferation 26754294 Process
5747 GO:1900024 IGI involved_in regulation of substrate adhesion-dependent cell spreading 19913511 Process
5747 GO:2000811 IMP involved_in negative regulation of anoikis 22402981 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5747 GO:0003779 IDA enables actin binding 16803572 Function
5747 GO:0004713 EXP enables protein tyrosine kinase activity 12235133,12391143,14676198 Function
5747 GO:0004715 IDA enables non-membrane spanning protein tyrosine kinase activity 10655584,11331870 Function
5747 GO:0004725 IMP enables protein tyrosine phosphatase activity 9360983 Function
5747 GO:0005178 IPI enables integrin binding 26763945 Function
5747 GO:0005515 IPI enables protein binding 7561682,7597091,8649368,9285683,9756887,9786953,10655584,10822..... Function
5747 GO:0008432 IDA enables JUN kinase binding 10925297 Function
5747 GO:0019901 IPI enables protein kinase binding 19118217 Function
5747 GO:0019903 IPI enables protein phosphatase binding 28759036 Function
5747 GO:0042169 IPI enables SH2 domain binding 15077193 Function
5747 GO:0140677 EXP enables molecular function activator activity 12467573 Function