Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:5976
  • Symbol:UPF1
  • Description:UPF1 RNA helicase and ATPase

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5976 GO:0000184 IDA involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 17468741 Process
5976 GO:0000184 IMP involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 18369367 Process
5976 GO:0000956 IMP involved_in nuclear-transcribed mRNA catabolic process 23828042 Process
5976 GO:0006260 IMP involved_in DNA replication 16488880 Process
5976 GO:0006281 IDA involved_in DNA repair 16488880 Process
5976 GO:0006449 IMP involved_in regulation of translational termination 9620853 Process
5976 GO:0032201 IDA involved_in telomere maintenance via semi-conservative replication 21829167 Process
5976 GO:0032204 IMP involved_in regulation of telomere maintenance 17916692 Process
5976 GO:0032508 IDA involved_in DNA duplex unwinding 30218034 Process
5976 GO:0044770 IMP involved_in cell cycle phase transition 16488880 Process
5976 GO:0061014 IDA involved_in positive regulation of mRNA catabolic process 24726324 Process
5976 GO:0061014 IMP involved_in positive regulation of mRNA catabolic process 25225333 Process
5976 GO:0061158 IDA involved_in 3'-UTR-mediated mRNA destabilization 24726324 Process
5976 GO:0071044 IMP involved_in histone mRNA catabolic process 16086026 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5976 GO:0000781 IDA located_in chromosome, telomeric region 21829167 Component
5976 GO:0000785 IDA part_of chromatin 16488880 Component
5976 GO:0005634 IDA located_in nucleus 18362360 Component
5976 GO:0005654 IDA located_in nucleoplasm Component
5976 GO:0005829 IDA located_in cytosol Component
5976 GO:0035145 IDA part_of exon-exon junction complex 16601204 Component
5976 GO:0044530 IDA part_of supraspliceosomal complex 18362360 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5976 GO:0003682 IDA enables chromatin binding 16488880 Function
5976 GO:0003723 HDA enables RNA binding 22658674,22681889 Function
5976 GO:0003723 IDA enables RNA binding 24726324 Function
5976 GO:0003724 IDA enables RNA helicase activity 12554878,21419344 Function
5976 GO:0005515 IPI enables protein binding 9620853,11163187,11544179,12417715,12881429,14636577,15680326,..... Function
5976 GO:0016887 IDA enables ATP hydrolysis activity 30218034 Function
5976 GO:0036121 IDA enables double-stranded DNA helicase activity 30218034 Function
5976 GO:0042162 IDA enables telomeric DNA binding 17916692,21829167 Function
5976 GO:0044877 IPI enables protein-containing complex binding 26841701 Function