Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:6093
  • Symbol:ROCK1
  • Description:Rho associated coiled-coil containing protein kinase 1

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6093 GO:0004674 IDA enables protein serine/threonine kinase activity 10652353,11018042,18694941,19036714,23093407 Function
6093 GO:0005515 IPI enables protein binding 10652353,14660612,17853893,20230755,21281639,22085929,23093407..... Function
6093 GO:0019828 IMP enables aspartic-type endopeptidase inhibitor activity 24305806 Function
6093 GO:0072518 IDA enables Rho-dependent protein serine/threonine kinase activity 18573880 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6093 GO:0006468 IDA involved_in protein phosphorylation 23093407 Process
6093 GO:0007159 IDA involved_in leukocyte cell-cell adhesion 12082081 Process
6093 GO:0007249 IMP involved_in I-kappaB kinase/NF-kappaB signaling 25816133 Process
6093 GO:0007266 IGI involved_in Rho protein signal transduction 27160703 Process
6093 GO:0010508 IGI involved_in positive regulation of autophagy 27853422 Process
6093 GO:0010613 IMP involved_in positive regulation of cardiac muscle hypertrophy 28679962 Process
6093 GO:0010628 IMP involved_in positive regulation of gene expression 27853422,28679962 Process
6093 GO:0010922 IMP involved_in positive regulation of phosphatase activity 27221467 Process
6093 GO:0016525 IMP involved_in negative regulation of angiogenesis 19181962 Process
6093 GO:0018105 IDA involved_in peptidyl-serine phosphorylation 18573880 Process
6093 GO:0022614 IDA involved_in membrane to membrane docking 12082081 Process
6093 GO:0030334 IDA involved_in regulation of cell migration 23093407 Process
6093 GO:0030866 IGI involved_in cortical actin cytoskeleton organization 25816133 Process
6093 GO:0030866 IMP involved_in cortical actin cytoskeleton organization 25816133 Process
6093 GO:0031175 IGI involved_in neuron projection development 27160703 Process
6093 GO:0032091 IDA involved_in negative regulation of protein binding 18573880 Process
6093 GO:0032956 IDA involved_in regulation of actin cytoskeleton organization 25911094 Process
6093 GO:0035306 IMP involved_in positive regulation of dephosphorylation 27221467 Process
6093 GO:0035509 IGI involved_in negative regulation of myosin-light-chain-phosphatase activity 25816133 Process
6093 GO:0035509 IMP involved_in negative regulation of myosin-light-chain-phosphatase activity 25816133 Process
6093 GO:0043410 IMP involved_in positive regulation of MAPK cascade 28679962 Process
6093 GO:0045616 IMP involved_in regulation of keratinocyte differentiation 19997641 Process
6093 GO:0045664 IGI involved_in regulation of neuron differentiation 27160703 Process
6093 GO:0050900 IDA involved_in leukocyte migration 12082081 Process
6093 GO:0050901 IDA involved_in leukocyte tethering or rolling 12082081 Process
6093 GO:0070507 IDA involved_in regulation of microtubule cytoskeleton organization 23093407 Process
6093 GO:0072659 IGI involved_in protein localization to plasma membrane 25816133 Process
6093 GO:0072659 IMP involved_in protein localization to plasma membrane 25816133 Process
6093 GO:0110061 IMP involved_in regulation of angiotensin-activated signaling pathway 28679962 Process
6093 GO:0140058 IGI involved_in neuron projection arborization 27160703 Process
6093 GO:1900223 IGI involved_in positive regulation of amyloid-beta clearance 27853422 Process
6093 GO:1900242 IGI involved_in regulation of synaptic vesicle endocytosis 27160703 Process
6093 GO:1902430 IMP involved_in negative regulation of amyloid-beta formation 24305806,27853422 Process
6093 GO:1902992 IMP involved_in negative regulation of amyloid precursor protein catabolic process 24305806,27853422 Process
6093 GO:1903140 IGI involved_in regulation of establishment of endothelial barrier 25816133 Process
6093 GO:1903140 IMP involved_in regulation of establishment of endothelial barrier 25816133 Process
6093 GO:1903347 IGI involved_in negative regulation of bicellular tight junction assembly 25816133 Process
6093 GO:1905205 IMP involved_in positive regulation of connective tissue replacement 28679962 Process