Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:6331
  • Symbol:SCN5A
  • Description:sodium voltage-gated channel alpha subunit 5

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6331 GO:0001518 IDA part_of voltage-gated sodium channel complex 19808477,20042427,21051419 Component
6331 GO:0005654 IDA located_in nucleoplasm Component
6331 GO:0005730 IDA located_in nucleolus Component
6331 GO:0005783 IDA located_in endoplasmic reticulum 22529811 Component
6331 GO:0005886 IDA located_in plasma membrane 16728661,17060380,22529811 Component
6331 GO:0005886 IMP located_in plasma membrane 23085483,26279430 Component
6331 GO:0005901 IDA located_in caveola 23420830 Component
6331 GO:0009986 IDA located_in cell surface 14500339,19666841,19943616 Component
6331 GO:0014704 IDA located_in intercalated disc 15579534 Component
6331 GO:0016020 IDA located_in membrane 19074138 Component
6331 GO:0030018 IDA located_in Z disc 19943616 Component
6331 GO:0030315 IDA located_in T-tubule 15579534 Component
6331 GO:0042383 IDA located_in sarcolemma 17060380 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6331 GO:0002027 IMP involved_in regulation of heart rate 10471492,18065446,18616619,21895525,22529811,23085483,26279430..... Process
6331 GO:0006814 IDA involved_in sodium ion transport 19074138,22514276 Process
6331 GO:0010765 IDA involved_in positive regulation of sodium ion transport 14500339,18065446,19808477,22529811 Process
6331 GO:0035725 IDA involved_in sodium ion transmembrane transport 14500339,19943616,21051419 Process
6331 GO:0035725 IMP involved_in sodium ion transmembrane transport 21895525,23085483,26279430,26392562 Process
6331 GO:0051899 IDA involved_in membrane depolarization 14500339,21051419,21895525 Process
6331 GO:0060048 IMP involved_in cardiac muscle contraction 18065446,21895525,22529811 Process
6331 GO:0060307 IMP involved_in regulation of ventricular cardiac muscle cell membrane repolarization 7889574 Process
6331 GO:0060371 IMP involved_in regulation of atrial cardiac muscle cell membrane depolarization 19167345,22247482 Process
6331 GO:0060372 IMP involved_in regulation of atrial cardiac muscle cell membrane repolarization 19167345 Process
6331 GO:0060373 IMP involved_in regulation of ventricular cardiac muscle cell membrane depolarization 7889574,18065446,22529811 Process
6331 GO:0071277 IDA involved_in cellular response to calcium ion 19074138 Process
6331 GO:0086002 IMP involved_in cardiac muscle cell action potential involved in contraction 21895525 Process
6331 GO:0086004 IMP involved_in regulation of cardiac muscle cell contraction 22529811 Process
6331 GO:0086005 IMP involved_in ventricular cardiac muscle cell action potential 22529811 Process
6331 GO:0086010 IDA involved_in membrane depolarization during action potential 14500339,18065446,22529811 Process
6331 GO:0086012 IMP involved_in membrane depolarization during cardiac muscle cell action potential 21895525 Process
6331 GO:0086014 IMP involved_in atrial cardiac muscle cell action potential 18065446 Process
6331 GO:0086015 IMP involved_in SA node cell action potential 18616619 Process
6331 GO:0086016 IMP involved_in AV node cell action potential 18616619 Process
6331 GO:0086043 IMP involved_in bundle of His cell action potential 18065446 Process
6331 GO:0086045 IMP involved_in membrane depolarization during AV node cell action potential 18616619 Process
6331 GO:0086046 IMP involved_in membrane depolarization during SA node cell action potential 18616619 Process
6331 GO:0086047 IMP involved_in membrane depolarization during Purkinje myocyte cell action potential 22766342 Process
6331 GO:0086048 IMP involved_in membrane depolarization during bundle of His cell action potential 18065446 Process
6331 GO:0086067 IMP involved_in AV node cell to bundle of His cell communication 10471492 Process
6331 GO:0086091 IMP involved_in regulation of heart rate by cardiac conduction 21895525 Process
6331 GO:0098912 IMP involved_in membrane depolarization during atrial cardiac muscle cell action potential 18065446 Process
6331 GO:1902305 IDA involved_in regulation of sodium ion transmembrane transport 18591664 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6331 GO:0005248 IDA enables voltage-gated sodium channel activity 14500339,19074138,19808477,19943616,21895525,22514276..... Function
6331 GO:0005248 IMP enables voltage-gated sodium channel activity 23085483,26279430,26392562 Function
6331 GO:0005515 IPI enables protein binding 16728661,16930557,18184654,18591664,19943616,22514276,22705208..... Function
6331 GO:0005516 IPI enables calmodulin binding 21167176 Function
6331 GO:0017134 IPI enables fibroblast growth factor binding 12401812 Function
6331 GO:0019899 IPI enables enzyme binding 19666841 Function
6331 GO:0019901 IPI enables protein kinase binding 22514276 Function
6331 GO:0019904 IPI enables protein domain specific binding 19943616 Function
6331 GO:0030506 IDA enables ankyrin binding 15579534 Function
6331 GO:0031625 IPI enables ubiquitin protein ligase binding 15217910 Function
6331 GO:0044325 IPI enables transmembrane transporter binding 17592081,20042427,24998131 Function
6331 GO:0050998 IPI enables nitric-oxide synthase binding 18591664 Function
6331 GO:0086006 IDA enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential 18065446 Function
6331 GO:0086006 IMP enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential 18616619,21895525,22529811 Function
6331 GO:0086060 IMP enables voltage-gated sodium channel activity involved in AV node cell action potential 18616619 Function
6331 GO:0086061 IMP enables voltage-gated sodium channel activity involved in bundle of His cell action potential 18065446 Function
6331 GO:0086062 IMP enables voltage-gated sodium channel activity involved in Purkinje myocyte action potential 22766342 Function
6331 GO:0086063 IMP enables voltage-gated sodium channel activity involved in SA node cell action potential 18616619 Function
6331 GO:0097110 IPI enables scaffold protein binding 17060380 Function