Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:641
  • Symbol:BLM
  • Description:BLM RecQ like helicase

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
641 GO:0000079 IMP involved_in regulation of cyclin-dependent protein serine/threonine kinase activity 15604258 Process
641 GO:0000724 IDA involved_in double-strand break repair via homologous recombination 23543748 Process
641 GO:0000729 IDA involved_in DNA double-strand break processing 21325134 Process
641 GO:0006974 IDA involved_in DNA damage response 23509288 Process
641 GO:0006974 IMP involved_in DNA damage response 12818200 Process
641 GO:0007095 IDA involved_in mitotic G2 DNA damage checkpoint signaling 11309417 Process
641 GO:0010165 IDA involved_in response to X-ray 11309417 Process
641 GO:0031297 IDA involved_in replication fork processing 17115688 Process
641 GO:0032508 IDA involved_in DNA duplex unwinding 11735402,24816114,25901030 Process
641 GO:0044806 IDA involved_in G-quadruplex DNA unwinding 11735402 Process
641 GO:0045893 IDA involved_in positive regulation of DNA-templated transcription 11781842 Process
641 GO:0045910 IMP involved_in negative regulation of DNA recombination 9671747 Process
641 GO:0051259 IDA involved_in protein complex oligomerization 28228481 Process
641 GO:0051260 IDA involved_in protein homooligomerization 28228481 Process
641 GO:0051782 IMP involved_in negative regulation of cell division 11781842 Process
641 GO:0061820 IDA involved_in telomeric D-loop disassembly 19734539 Process
641 GO:0071139 IDA involved_in resolution of recombination intermediates 23543748 Process
641 GO:0071479 IDA involved_in cellular response to ionizing radiation 23509288 Process
641 GO:0072711 IDA involved_in cellular response to hydroxyurea 23509288 Process
641 GO:0072757 IDA involved_in cellular response to camptothecin 23509288 Process
641 GO:0090329 IMP involved_in regulation of DNA-templated DNA replication 25901030 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
641 GO:0000228 IDA located_in nuclear chromosome 23509288 Component
641 GO:0000781 IDA colocalizes_with chromosome, telomeric region 10779560 Component
641 GO:0000800 IDA located_in lateral element 10728666 Component
641 GO:0005634 IDA located_in nucleus 9388480,11500040 Component
641 GO:0005654 IDA located_in nucleoplasm Component
641 GO:0005730 IDA located_in nucleolus 10779560 Component
641 GO:0005829 IDA located_in cytosol Component
641 GO:0016363 IDA located_in nuclear matrix 11309417 Component
641 GO:0016605 IDA colocalizes_with PML body 10779560 Component
641 GO:0016605 IDA located_in PML body 10728666 Component
641 GO:0031422 IPI part_of RecQ family helicase-topoisomerase III complex 24984776 Component
641 GO:0032991 IDA part_of protein-containing complex 10359700 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
641 GO:0000400 IDA enables four-way junction DNA binding 11735402,20639533,25901030 Function
641 GO:0000403 IDA enables Y-form DNA binding 11735402 Function
641 GO:0000405 IDA enables bubble DNA binding 11433031,11735402 Function
641 GO:0002039 IPI enables p53 binding 11781842 Function
641 GO:0003677 IDA enables DNA binding 24257077,24816114 Function
641 GO:0003678 IDA enables DNA helicase activity 9388193,12181313,12818200,17878217,19734539,24816114,25901030..... Function
641 GO:0003678 IMP enables DNA helicase activity 21325134 Function
641 GO:0003697 IDA enables single-stranded DNA binding 12818200,20639533 Function
641 GO:0004386 IDA enables helicase activity 10871376 Function
641 GO:0005515 IPI enables protein binding 10728666,10825162,11309417,11919194,12181313,12975363,14688284..... Function
641 GO:0005524 IDA enables ATP binding 24816114,25901030 Function
641 GO:0008094 IDA enables ATP-dependent activity, acting on DNA 10359700,24816114,25901030 Function
641 GO:0008270 IDA enables zinc ion binding 24816114,25901030 Function
641 GO:0009378 IDA enables four-way junction helicase activity 11433031,11735402,12818200,25901030 Function
641 GO:0042802 IDA enables identical protein binding 10359700 Function
641 GO:0042803 IDA enables protein homodimerization activity 28228481 Function
641 GO:0051880 IDA enables G-quadruplex DNA binding 11433031,11735402 Function
641 GO:0061749 IDA enables forked DNA-dependent helicase activity 11735402,25901030 Function
641 GO:0061821 IDA enables telomeric D-loop binding 19734539 Function
641 GO:0061849 IDA enables telomeric G-quadruplex DNA binding 19734539 Function
641 GO:0140677 IDA enables molecular function activator activity 24257077 Function
641 GO:1905773 IDA enables 8-hydroxy-2'-deoxyguanosine DNA binding 19734539 Function
641 GO:1990814 IDA enables DNA/DNA annealing activity 17878217 Function