Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:6422
  • Symbol:SFRP1
  • Description:secreted frizzled related protein 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6422 GO:0001649 IEP involved_in osteoblast differentiation 16149051 Process
6422 GO:0002244 IDA involved_in hematopoietic progenitor cell differentiation 19778523 Process
6422 GO:0008284 IDA involved_in positive regulation of cell population proliferation 10980594 Process
6422 GO:0008285 IDA involved_in negative regulation of cell population proliferation 10347172,17443492,17994217,19277043,20208569 Process
6422 GO:0009267 IEP involved_in cellular response to starvation 9724099,11932307 Process
6422 GO:0009950 IDA involved_in dorsal/ventral axis specification 9192640 Process
6422 GO:0010564 IMP involved_in regulation of cell cycle process 9724099 Process
6422 GO:0010629 IDA involved_in negative regulation of gene expression 10980594 Process
6422 GO:0010719 IDA involved_in negative regulation of epithelial to mesenchymal transition 19095296 Process
6422 GO:0014070 IDA involved_in response to organic cyclic compound 20208569 Process
6422 GO:0030177 IDA involved_in positive regulation of Wnt signaling pathway 10660608 Process
6422 GO:0030178 IDA involved_in negative regulation of Wnt signaling pathway 9192640,10660608,17500071,20208569 Process
6422 GO:0030279 IDA involved_in negative regulation of ossification 15677765 Process
6422 GO:0030279 IMP involved_in negative regulation of ossification 19254787 Process
6422 GO:0030307 IDA involved_in positive regulation of cell growth 10980594,16288033 Process
6422 GO:0030308 IDA involved_in negative regulation of cell growth 19569235,20208569 Process
6422 GO:0030336 IDA involved_in negative regulation of cell migration 10980594 Process
6422 GO:0033689 IMP involved_in negative regulation of osteoblast proliferation 19072540 Process
6422 GO:0043065 IDA involved_in positive regulation of apoptotic process 9391078,15677765 Process
6422 GO:0043065 IMP involved_in positive regulation of apoptotic process 9724099,16149051,16288033,19254787 Process
6422 GO:0043066 IMP involved_in negative regulation of apoptotic process 11932307,14581477,16149051,16288033,19723665 Process
6422 GO:0044344 IDA involved_in cellular response to fibroblast growth factor stimulus 17500071 Process
6422 GO:0045578 IMP involved_in negative regulation of B cell differentiation 18941195 Process
6422 GO:0045600 IDA acts_upstream_of_or_within positive regulation of fat cell differentiation 12055200 Process
6422 GO:0045600 IDA involved_in positive regulation of fat cell differentiation 15886250 Process
6422 GO:0045880 IMP involved_in positive regulation of smoothened signaling pathway 17035233 Process
6422 GO:0045892 IDA involved_in negative regulation of DNA-templated transcription 10660608,19095296,19277043,20234818 Process
6422 GO:0045892 IMP involved_in negative regulation of DNA-templated transcription 16532032 Process
6422 GO:0045893 IDA involved_in positive regulation of DNA-templated transcription 10660608,15886250,19569235 Process
6422 GO:0045893 IMP involved_in positive regulation of DNA-templated transcription 19723665 Process
6422 GO:0046676 IDA involved_in negative regulation of insulin secretion 17994217 Process
6422 GO:0046851 IMP involved_in negative regulation of bone remodeling 19072540 Process
6422 GO:0048147 IDA involved_in negative regulation of fibroblast proliferation 19734317 Process
6422 GO:0050679 IMP involved_in positive regulation of epithelial cell proliferation 16288033 Process
6422 GO:0050680 IDA involved_in negative regulation of epithelial cell proliferation 19095296 Process
6422 GO:0050732 IDA involved_in negative regulation of peptidyl-tyrosine phosphorylation 10980594 Process
6422 GO:0060070 IDA involved_in canonical Wnt signaling pathway 18787224 Process
6422 GO:0060218 IDA involved_in hematopoietic stem cell differentiation 19778523 Process
6422 GO:0060766 IDA involved_in negative regulation of androgen receptor signaling pathway 19277043 Process
6422 GO:0071305 IEP involved_in cellular response to vitamin D 16149051 Process
6422 GO:0071347 IEP involved_in cellular response to interleukin-1 16149051 Process
6422 GO:0071356 IDA involved_in cellular response to tumor necrosis factor 9391078 Process
6422 GO:0071363 IDA involved_in cellular response to growth factor stimulus 17500071 Process
6422 GO:0071380 IEP involved_in cellular response to prostaglandin E stimulus 16149051 Process
6422 GO:0071391 IDA involved_in cellular response to estrogen stimulus 18941195 Process
6422 GO:0071392 IEP involved_in cellular response to estradiol stimulus 11932307 Process
6422 GO:0071456 IEP involved_in cellular response to hypoxia 11932307 Process
6422 GO:0071504 IDA involved_in cellular response to heparin 17500071 Process
6422 GO:0071560 IEP involved_in cellular response to transforming growth factor beta stimulus 16149051 Process
6422 GO:0071773 IEP involved_in cellular response to BMP stimulus 16149051 Process
6422 GO:0090090 IDA involved_in negative regulation of canonical Wnt signaling pathway 9391078,10347172,16149051,16288033,17443492,17471511,19095296,..... Process
6422 GO:0090090 IGI involved_in negative regulation of canonical Wnt signaling pathway 17462603,24080158 Process
6422 GO:0090090 IMP involved_in negative regulation of canonical Wnt signaling pathway 9724099,16532032,17035233,19072540,19254787 Process
6422 GO:0090263 IDA involved_in positive regulation of canonical Wnt signaling pathway 18941195 Process
6422 GO:0090263 IGI involved_in positive regulation of canonical Wnt signaling pathway 24080158 Process
6422 GO:1902043 IDA involved_in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 9391078 Process
6422 GO:2000052 IDA involved_in positive regulation of non-canonical Wnt signaling pathway 19569235 Process
6422 GO:2000054 IDA involved_in negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification 9192640 Process
6422 GO:2000080 IDA involved_in negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation 17994217 Process
6422 GO:2000270 IDA involved_in negative regulation of fibroblast apoptotic process 14581477 Process
6422 GO:2000271 IDA involved_in positive regulation of fibroblast apoptotic process 14581477 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6422 GO:0004197 IMP enables cysteine-type endopeptidase activity 14581477 Function
6422 GO:0005109 IPI enables frizzled binding 1927703,10347172,19277043 Function
6422 GO:0005515 IPI enables protein binding 10347172,32296183 Function
6422 GO:0008201 IDA enables heparin binding 9192640,10660608,11741940 Function
6422 GO:0017147 IDA enables Wnt-protein binding 17462603 Function
6422 GO:0017147 IPI enables Wnt-protein binding 10347172,10660608,17462603,19072540,24080158 Function
6422 GO:0042802 IPI enables identical protein binding 10347172 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6422 GO:0005615 HDA located_in extracellular space 20551380 Component
6422 GO:0005615 IDA located_in extracellular space 9192640,10980594,17500071 Component
6422 GO:0005829 IDA located_in cytosol 14581477 Component
6422 GO:0009986 IDA located_in cell surface 9192640 Component
6422 GO:0062023 HDA colocalizes_with collagen-containing extracellular matrix 20551380 Component
6422 GO:0062023 HDA located_in collagen-containing extracellular matrix 27559042 Component
6422 GO:0062023 IDA located_in collagen-containing extracellular matrix 9192640,10347172 Component
6422 GO:0070062 HDA located_in extracellular exosome 19199708 Component