Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:6683
  • Symbol:SPAST
  • Description:spastin

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6683 GO:0000281 IMP involved_in mitotic cytokinesis 21310966 Process
6683 GO:0001578 IDA involved_in microtubule bundle formation 16219033 Process
6683 GO:0006888 IMP involved_in endoplasmic reticulum to Golgi vesicle-mediated transport 19000169 Process
6683 GO:0010458 IMP involved_in exit from mitosis 26040712 Process
6683 GO:0031468 IMP involved_in nuclear membrane reassembly 26040712 Process
6683 GO:0032467 IMP involved_in positive regulation of cytokinesis 18997780 Process
6683 GO:0032506 IMP involved_in cytokinetic process 19000169 Process
6683 GO:0034214 IDA involved_in protein hexamerization 17389232 Process
6683 GO:0051013 IDA involved_in microtubule severing 15716377,16219033,17389232,23745751,26875866 Process
6683 GO:0051013 IMP involved_in microtubule severing 21310966 Process
6683 GO:0051228 IMP involved_in mitotic spindle disassembly 26040712 Process
6683 GO:0051260 IDA involved_in protein homooligomerization 17389232 Process
6683 GO:0090148 IMP involved_in membrane fission 21310966 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6683 GO:0000922 IDA located_in spindle pole 15269182 Component
6683 GO:0005634 IDA located_in nucleus 15147984,15269182,16026783,19000169 Component
6683 GO:0005654 IDA located_in nucleoplasm Component
6683 GO:0005737 IDA located_in cytoplasm 16026783,19000169,21545838 Component
6683 GO:0005768 IDA colocalizes_with endosome 19000169 Component
6683 GO:0005783 IDA colocalizes_with endoplasmic reticulum 19000169 Component
6683 GO:0005813 IDA located_in centrosome 25390646 Component
6683 GO:0005829 IDA located_in cytosol Component
6683 GO:0015630 IDA colocalizes_with microtubule cytoskeleton 15716377,17389232,19000169 Component
6683 GO:0030424 IDA located_in axon 15269182 Component
6683 GO:0030496 IDA colocalizes_with midbody 19000169 Component
6683 GO:0030496 IDA located_in midbody 15269182,21310966 Component
6683 GO:0030496 IMP located_in midbody 18997780 Component
6683 GO:0031410 IDA located_in cytoplasmic vesicle 21545838 Component
6683 GO:0031965 IMP located_in nuclear membrane 26040712 Component
6683 GO:0048471 IDA located_in perinuclear region of cytoplasm 15147984 Component
6683 GO:0070062 HDA located_in extracellular exosome 19056867 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6683 GO:0005515 IPI enables protein binding 16815977,17389232,18997780,20200447,20719964,23969831,25390646..... Function
6683 GO:0008017 IDA enables microtubule binding 15716377,16219033,17389232,23745751,34970964 Function
6683 GO:0008568 IDA enables microtubule severing ATPase activity 15716377,16219033,17389232,23745751,26875866 Function
6683 GO:0043014 IPI enables alpha-tubulin binding 17389232 Function
6683 GO:0048487 IDA enables beta-tubulin binding 26875866 Function
6683 GO:0048487 IPI enables beta-tubulin binding 17389232 Function