Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:672
  • Symbol:BRCA1
  • Description:BRCA1 DNA repair associated

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
672 GO:0000152 IDA part_of nuclear ubiquitin ligase complex 14636569 Component
672 GO:0000800 IDA located_in lateral element 9774970 Component
672 GO:0005634 IDA located_in nucleus 9342365,14636569,17525340,17643121,20160719,23855721,26833090..... Component
672 GO:0005654 IDA located_in nucleoplasm Component
672 GO:0005737 IDA located_in cytoplasm 20160719 Component
672 GO:0005886 IDA located_in plasma membrane 21282464 Component
672 GO:0016604 IDA located_in nuclear body Component
672 GO:0031436 IDA part_of BRCA1-BARD1 complex 12890688,15265711,19117993,20351172 Component
672 GO:0031436 IPI part_of BRCA1-BARD1 complex 11573085 Component
672 GO:0032991 IDA part_of protein-containing complex 9774970 Component
672 GO:0043232 IDA is_active_in intracellular non-membrane-bounded organelle 9008167 Component
672 GO:0070531 IDA part_of BRCA1-A complex 17525340,17525341,17525342,19261748,19261749 Component
672 GO:0070532 IPI part_of BRCA1-B complex 16391231 Component
672 GO:0070533 IPI part_of BRCA1-C complex 16391231 Component
672 GO:1990391 IPI part_of DNA repair complex 19369211 Component
672 GO:1990904 IDA part_of ribonucleoprotein complex 18809582 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
672 GO:0000209 IDA involved_in protein polyubiquitination 12485996 Process
672 GO:0000724 IDA involved_in double-strand break repair via homologous recombination 17349954,28398198 Process
672 GO:0006301 IDA involved_in postreplication repair 17349954 Process
672 GO:0006302 IDA involved_in double-strand break repair 22186889 Process
672 GO:0006302 IMP involved_in double-strand break repair 17525340,17643121,19261748 Process
672 GO:0006357 IMP involved_in regulation of transcription by RNA polymerase II 9662397 Process
672 GO:0007059 IMP involved_in chromosome segregation 15965487 Process
672 GO:0007095 IMP involved_in mitotic G2 DNA damage checkpoint signaling 17525340,17643121,19261748 Process
672 GO:0008630 IDA acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage 14654789 Process
672 GO:0010212 IMP involved_in response to ionizing radiation 17525340,17643121,19261748 Process
672 GO:0010575 IMP involved_in positive regulation of vascular endothelial growth factor production 23415688 Process
672 GO:0010628 IMP involved_in positive regulation of gene expression 23415688 Process
672 GO:0016567 IDA involved_in protein ubiquitination 17349954 Process
672 GO:0030308 IMP involved_in negative regulation of cell growth 10518542 Process
672 GO:0031398 IDA involved_in positive regulation of protein ubiquitination 15965487 Process
672 GO:0033147 IMP involved_in negative regulation of intracellular estrogen receptor signaling pathway 17505062 Process
672 GO:0035066 IDA involved_in positive regulation of histone acetylation 20820192 Process
672 GO:0043627 IDA involved_in response to estrogen 8895509 Process
672 GO:0045717 IMP involved_in negative regulation of fatty acid biosynthetic process 16326698 Process
672 GO:0045739 IMP involved_in positive regulation of DNA repair 17525340,17643121,19261748 Process
672 GO:0045766 IMP involved_in positive regulation of angiogenesis 23415688 Process
672 GO:0045892 IDA involved_in negative regulation of DNA-templated transcription 16288014 Process
672 GO:0045893 IDA involved_in positive regulation of DNA-templated transcription 20160719 Process
672 GO:0045893 IMP involved_in positive regulation of DNA-templated transcription 12080089 Process
672 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 16331276 Process
672 GO:0045944 IMP involved_in positive regulation of transcription by RNA polymerase II 20820192 Process
672 GO:0051179 IDA involved_in localization 9008167 Process
672 GO:0051571 IDA involved_in positive regulation of histone H3-K4 methylation 20820192 Process
672 GO:0051573 IDA involved_in negative regulation of histone H3-K9 methylation 20820192 Process
672 GO:0051726 IDA acts_upstream_of regulation of cell cycle 21102443 Process
672 GO:0051865 IDA involved_in protein autoubiquitination 12890688,20351172 Process
672 GO:0070512 IDA involved_in positive regulation of histone H4-K20 methylation 20820192 Process
672 GO:0071356 IMP involved_in cellular response to tumor necrosis factor 23415688 Process
672 GO:0071479 IMP involved_in cellular response to ionizing radiation 14636569 Process
672 GO:0071681 IDA involved_in cellular response to indole-3-methanol 10868478 Process
672 GO:0085020 IDA involved_in protein K6-linked ubiquitination 12890688,20351172 Process
672 GO:1902042 IMP involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 23415688 Process
672 GO:2000378 IMP involved_in negative regulation of reactive oxygen species metabolic process 23415688 Process
672 GO:2000617 IDA involved_in positive regulation of histone H3-K9 acetylation 20820192 Process
672 GO:2000620 IDA involved_in positive regulation of histone H4-K16 acetylation 20820192 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
672 GO:0000976 IDA enables transcription cis-regulatory region binding 20820192 Function
672 GO:0002039 IDA enables p53 binding 15571721 Function
672 GO:0003713 IMP enables transcription coactivator activity 9662397 Function
672 GO:0003723 IDA enables RNA binding 12419249 Function
672 GO:0004842 IDA enables ubiquitin-protein transferase activity 12890688,17349954,19117993,20351172 Function
672 GO:0005515 IPI enables protein binding 8944023,9497340,9528852,9662397,9774970,9811458,10477523,10518..... Function
672 GO:0019899 IPI enables enzyme binding 15965487 Function
672 GO:0031625 IPI enables ubiquitin protein ligase binding 17873885 Function
672 GO:0042802 IPI enables identical protein binding 8944023,29656893,34591612 Function
672 GO:0070063 IDA enables RNA polymerase binding 9662397 Function