Gene Ontology

Gene Info

• Species:Human (Homo sapiens)
• GeneID:6720
• Symbol:SREBF1
• Description:sterol regulatory element binding transcription factor 1

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
6720	GO:0000977	IDA	enables	RNA polymerase II transcription regulatory region sequence-specific DNA binding	23610160	Function
6720	GO:0000981	IDA	enables	DNA-binding transcription factor activity, RNA polymerase II-specific	12177166	Function
6720	GO:0000981	IMP	enables	DNA-binding transcription factor activity, RNA polymerase II-specific	32497488	Function
6720	GO:0001221	IPI	enables	transcription coregulator binding	14701856	Function
6720	GO:0001228	IDA	enables	DNA-binding transcription activator activity, RNA polymerase II-specific	31501273	Function
6720	GO:0003700	IDA	enables	DNA-binding transcription factor activity	16407292	Function
6720	GO:0004879	IDA	enables	nuclear receptor activity	23610160	Function
6720	GO:0005515	IPI	enables	protein binding	16713569,23610160,32814053	Function
6720	GO:0032810	IDA	enables	sterol response element binding	16407292,31501273	Function
6720	GO:1990837	IDA	enables	sequence-specific double-stranded DNA binding	28473536	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
6720	GO:0005634	IDA	located_in	nucleus	15358760	Component
6720	GO:0005634	IMP	located_in	nucleus	32497488	Component

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
6720	GO:0008610	IMP	involved_in	lipid biosynthetic process	32497488	Process
6720	GO:0031647	IMP	involved_in	regulation of protein stability	24912190	Process
6720	GO:0032933	IDA	involved_in	SREBP signaling pathway	27614840	Process
6720	GO:0032933	IMP	involved_in	SREBP signaling pathway	27614840	Process
6720	GO:0045542	IDA	involved_in	positive regulation of cholesterol biosynthetic process	12177166	Process
6720	GO:0045542	IMP	involved_in	positive regulation of cholesterol biosynthetic process	12177166	Process
6720	GO:0045944	IDA	involved_in	positive regulation of transcription by RNA polymerase II	26437365,31501273	Process
6720	GO:0045944	IGI	involved_in	positive regulation of transcription by RNA polymerase II	23610160	Process
6720	GO:0090209	IDA	acts_upstream_of	negative regulation of triglyceride metabolic process	28483554	Process
6720	GO:1902895	IDA	involved_in	positive regulation of miRNA transcription	31501273	Process
6720	GO:1903146	IMP	involved_in	regulation of autophagy of mitochondrion	24912190	Process
6720	GO:1903214	IMP	involved_in	regulation of protein targeting to mitochondrion	24912190	Process