Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:6721
  • Symbol:SREBF2
  • Description:sterol regulatory element binding transcription factor 2

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6721 GO:0000122 IDA involved_in negative regulation of transcription by RNA polymerase II 15358760,19098903 Process
6721 GO:0009267 IMP involved_in cellular response to starvation 25339898 Process
6721 GO:0010886 IDA acts_upstream_of positive regulation of cholesterol storage 15358760 Process
6721 GO:0032933 IDA involved_in SREBP signaling pathway 27614840 Process
6721 GO:0032933 IMP involved_in SREBP signaling pathway 27614840 Process
6721 GO:0045542 IDA involved_in positive regulation of cholesterol biosynthetic process 12177166 Process
6721 GO:0045944 IDA acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 12446768 Process
6721 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 12242332 Process
6721 GO:0071404 IEP involved_in cellular response to low-density lipoprotein particle stimulus 15358760 Process
6721 GO:0090370 IDA acts_upstream_of negative regulation of cholesterol efflux 15358760 Process
6721 GO:1903146 HMP involved_in regulation of autophagy of mitochondrion 24912190 Process
6721 GO:1903955 HMP involved_in positive regulation of protein targeting to mitochondrion 24912190 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6721 GO:0000247 IDA NOT enables C-8 sterol isomerase activity 12941800 Function
6721 GO:0000978 IDA enables RNA polymerase II cis-regulatory region sequence-specific DNA binding 15358760 Function
6721 GO:0000981 IDA enables DNA-binding transcription factor activity, RNA polymerase II-specific 12177166 Function
6721 GO:0001227 IDA enables DNA-binding transcription repressor activity, RNA polymerase II-specific 15358760 Function
6721 GO:0005515 IPI enables protein binding 9242699,10976766,12855700,16799563,19706601,20936779,22265415,..... Function
6721 GO:0070888 IDA enables E-box binding 15358760 Function
6721 GO:1990837 IDA enables sequence-specific double-stranded DNA binding 28473536 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6721 GO:0005634 IDA located_in nucleus 12202038,12242332,12941800,15358760,19098903 Component
6721 GO:0005654 IDA located_in nucleoplasm Component
6721 GO:0005737 IDA located_in cytoplasm 12941800,19098903 Component
6721 GO:0005783 IDA located_in endoplasmic reticulum 12202038,12941800 Component
6721 GO:0032937 IDA part_of SREBP-SCAP-Insig complex 12202038,12242332 Component
6721 GO:0043231 IDA located_in intracellular membrane-bounded organelle Component