Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:6910
  • Symbol:TBX5
  • Description:T-box transcription factor 5

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6910 GO:0000978 IDA enables RNA polymerase II cis-regulatory region sequence-specific DNA binding 26926761 Function
6910 GO:0000981 IDA enables DNA-binding transcription factor activity, RNA polymerase II-specific 29174768 Function
6910 GO:0003677 IDA enables DNA binding 16332960 Function
6910 GO:0003700 IDA enables DNA-binding transcription factor activity 11431700,12499378,16332960 Function
6910 GO:0003700 IMP enables DNA-binding transcription factor activity 11431700 Function
6910 GO:0005515 IPI enables protein binding 11431700,12499378,12845333,16332960,23245941,24000169,26926761..... Function
6910 GO:0043565 IDA enables sequence-specific DNA binding 11431700,12499378 Function
6910 GO:0061629 IPI enables RNA polymerase II-specific DNA-binding transcription factor binding 11431700 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6910 GO:0005634 IDA located_in nucleus 12237100,12499378,14519429,29174768 Component
6910 GO:0005737 IDA located_in cytoplasm 14519429,29174768 Component
6910 GO:0032991 IDA part_of protein-containing complex 26926761 Component
6910 GO:0032993 IDA part_of protein-DNA complex 26926761 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
6910 GO:0007267 IDA involved_in cell-cell signaling 11161571 Process
6910 GO:0007507 IDA involved_in heart development 15138308 Process
6910 GO:0007507 IMP acts_upstream_of_or_within heart development 8988164,8988165 Process
6910 GO:0007507 IMP involved_in heart development 8988165,16183809,25963046 Process
6910 GO:0008285 IDA involved_in negative regulation of cell population proliferation 11161571,12237100 Process
6910 GO:0030326 IMP involved_in embryonic limb morphogenesis 8988164 Process
6910 GO:0030336 IDA involved_in negative regulation of cell migration 15138308 Process
6910 GO:0035115 IMP involved_in embryonic forelimb morphogenesis 16183809 Process
6910 GO:0035136 IMP acts_upstream_of_or_within forelimb morphogenesis 8988164,8988165 Process
6910 GO:0045893 IDA involved_in positive regulation of DNA-templated transcription 11431700,12499378,12845333,16332960,27035640 Process
6910 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 29174768 Process
6910 GO:0045944 IMP involved_in positive regulation of transcription by RNA polymerase II 11431700 Process
6910 GO:0051891 IDA involved_in positive regulation of cardioblast differentiation 11431700 Process
6910 GO:0060039 IDA involved_in pericardium development 15138308 Process
6910 GO:0060044 IDA involved_in negative regulation of cardiac muscle cell proliferation 11161571 Process