Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:7057
  • Symbol:THBS1
  • Description:thrombospondin 1

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
7057 GO:0001786 IDA enables phosphatidylserine binding 18940719 Function
7057 GO:0001968 IDA enables fibronectin binding 6693501,18042364 Function
7057 GO:0002020 IPI enables protease binding 7679575 Function
7057 GO:0004866 IDA enables endopeptidase inhibitor activity 7679575 Function
7057 GO:0005178 IMP enables integrin binding 17413041,18757424 Function
7057 GO:0005201 HDA enables extracellular matrix structural constituent 28344315 Function
7057 GO:0005515 IPI enables protein binding 3402455,6438154,11134179,15700281,15864306,18042364,18688696,1..... Function
7057 GO:0008201 IDA enables heparin binding 101549,8288588 Function
7057 GO:0017134 IDA enables fibroblast growth factor binding 17996481 Function
7057 GO:0030169 IDA enables low-density lipoprotein particle binding 6693501 Function
7057 GO:0042803 IPI enables protein homodimerization activity 7679575 Function
7057 GO:0043236 IDA enables laminin binding 6693501 Function
7057 GO:0070051 IDA enables fibrinogen binding 6693501 Function
7057 GO:0070052 IDA enables collagen V binding 6693501 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
7057 GO:0001937 IDA acts_upstream_of_or_within negative regulation of endothelial cell proliferation 16150726 Process
7057 GO:0001937 IDA involved_in negative regulation of endothelial cell proliferation 17996481 Process
7057 GO:0001937 IMP involved_in negative regulation of endothelial cell proliferation 17413041 Process
7057 GO:0001953 IDA acts_upstream_of_or_within negative regulation of cell-matrix adhesion 16150726 Process
7057 GO:0001953 IDA involved_in negative regulation of cell-matrix adhesion 17416590 Process
7057 GO:0002040 IMP involved_in sprouting angiogenesis 17879962 Process
7057 GO:0002544 IEP involved_in chronic inflammatory response 18674744 Process
7057 GO:0002581 IDA involved_in negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 16882710 Process
7057 GO:0002605 IDA involved_in negative regulation of dendritic cell antigen processing and presentation 16882710 Process
7057 GO:0006954 IDA involved_in inflammatory response 23144964 Process
7057 GO:0006955 IEP involved_in immune response 18674744 Process
7057 GO:0008284 IDA involved_in positive regulation of cell population proliferation 24615654 Process
7057 GO:0008285 IDA involved_in negative regulation of cell population proliferation 17596205 Process
7057 GO:0009410 IEP involved_in response to xenobiotic stimulus 19738618 Process
7057 GO:0009749 IDA involved_in response to glucose 18096704 Process
7057 GO:0010595 IDA involved_in positive regulation of endothelial cell migration 18555217 Process
7057 GO:0010596 IDA involved_in negative regulation of endothelial cell migration 18555217 Process
7057 GO:0010748 IDA involved_in negative regulation of long-chain fatty acid import across plasma membrane 17416590 Process
7057 GO:0010751 IDA acts_upstream_of_or_within negative regulation of nitric oxide mediated signal transduction 16150726 Process
7057 GO:0010751 IDA involved_in negative regulation of nitric oxide mediated signal transduction 17416590 Process
7057 GO:0010754 IDA involved_in negative regulation of cGMP-mediated signaling 17416590 Process
7057 GO:0010757 IDA involved_in negative regulation of plasminogen activation 6438154 Process
7057 GO:0010763 IDA involved_in positive regulation of fibroblast migration 18555217 Process
7057 GO:0016477 IDA involved_in cell migration 18555217 Process
7057 GO:0016525 IDA acts_upstream_of_or_within negative regulation of angiogenesis 16150726 Process
7057 GO:0016525 IDA involved_in negative regulation of angiogenesis 17596205,17996481,18726995 Process
7057 GO:0016525 IMP involved_in negative regulation of angiogenesis 24177325 Process
7057 GO:0018149 IDA involved_in peptide cross-linking 3997886 Process
7057 GO:0030194 IDA involved_in positive regulation of blood coagulation 3997886 Process
7057 GO:0030335 IDA involved_in positive regulation of cell migration 15700281 Process
7057 GO:0030335 IMP involved_in positive regulation of cell migration 17413041 Process
7057 GO:0030511 IDA involved_in positive regulation of transforming growth factor beta receptor signaling pathway 18555217 Process
7057 GO:0032026 IDA involved_in response to magnesium ion 6777381 Process
7057 GO:0032695 IDA involved_in negative regulation of interleukin-12 production 16882710 Process
7057 GO:0032760 IDA involved_in positive regulation of tumor necrosis factor production 18726995 Process
7057 GO:0040037 IDA involved_in negative regulation of fibroblast growth factor receptor signaling pathway 17996481 Process
7057 GO:0042327 IMP involved_in positive regulation of phosphorylation 17413041 Process
7057 GO:0043032 IDA involved_in positive regulation of macrophage activation 18757424 Process
7057 GO:0043066 IDA involved_in negative regulation of apoptotic process 18653767 Process
7057 GO:0043154 IDA involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 18653767 Process
7057 GO:0043406 IMP acts_upstream_of positive regulation of MAP kinase activity 17413041 Process
7057 GO:0043536 IDA involved_in positive regulation of blood vessel endothelial cell migration 18555217 Process
7057 GO:0043537 IDA involved_in negative regulation of blood vessel endothelial cell migration 18555217 Process
7057 GO:0043652 IDA involved_in engulfment of apoptotic cell 16882710 Process
7057 GO:0045727 IDA involved_in positive regulation of translation 15700281 Process
7057 GO:0045766 IMP involved_in positive regulation of angiogenesis 17413041,17879962 Process
7057 GO:0048661 IDA involved_in positive regulation of smooth muscle cell proliferation 24615654 Process
7057 GO:0050921 IDA involved_in positive regulation of chemotaxis 18555217 Process
7057 GO:0051592 IDA involved_in response to calcium ion 6777381,18757424 Process
7057 GO:0051897 IDA involved_in positive regulation of protein kinase B signaling 18653767 Process
7057 GO:0051918 IDA involved_in negative regulation of fibrinolysis 6438154 Process
7057 GO:0090051 IMP involved_in negative regulation of cell migration involved in sprouting angiogenesis 25660232 Process
7057 GO:1902043 IDA involved_in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors 18726995 Process
7057 GO:1903588 IMP involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 25660232 Process
7057 GO:1903671 IGI involved_in negative regulation of sprouting angiogenesis 28124060 Process
7057 GO:2000353 IDA involved_in positive regulation of endothelial cell apoptotic process 18726995 Process
7057 GO:2000379 IDA involved_in positive regulation of reactive oxygen species metabolic process 18757424 Process
7057 GO:2001027 IDA acts_upstream_of_or_within negative regulation of endothelial cell chemotaxis 16150726 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
7057 GO:0005576 HDA located_in extracellular region 27068509 Component
7057 GO:0005577 IDA part_of fibrinogen complex 3997886 Component
7057 GO:0005615 HDA located_in extracellular space 16502470,20551380 Component
7057 GO:0005615 IDA located_in extracellular space 6777381,26395742 Component
7057 GO:0009897 IDA located_in external side of plasma membrane 6777381 Component
7057 GO:0009986 IDA located_in cell surface 2435757,3084490,6777381 Component
7057 GO:0030141 IDA located_in secretory granule 101549 Component
7057 GO:0031012 IDA located_in extracellular matrix 6341993 Component
7057 GO:0031091 IDA located_in platelet alpha granule 6777381 Component
7057 GO:0062023 HDA colocalizes_with collagen-containing extracellular matrix 20551380 Component
7057 GO:0062023 HDA located_in collagen-containing extracellular matrix 23658023,23979707,28327460,28344315 Component
7057 GO:0070062 HDA located_in extracellular exosome 19056867,19199708,21362503,23533145 Component