Gene Ontology

Gene Info

  • Species: Human (Homo sapiens)
  • GeneID: 7415
  • Symbol: VCP
  • Description: valosin containing protein

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
7415 GO:0000502 IDA part_of proteasome complex 9452483 Component
7415 GO:0005634 HDA located_in nucleus 21630459 Component
7415 GO:0005634 IDA located_in nucleus 10855792,26842564 Component
7415 GO:0005654 IDA located_in nucleoplasm Component
7415 GO:0005737 IDA located_in cytoplasm 27753622 Component
7415 GO:0005783 IDA located_in endoplasmic reticulum 15215856,24089527 Component
7415 GO:0005789 IDA is_active_in endoplasmic reticulum membrane 24129571 Component
7415 GO:0005789 IDA located_in endoplasmic reticulum membrane 17872946 Component
7415 GO:0005811 IDA located_in lipid droplet 23297223 Component
7415 GO:0005829 IDA located_in cytosol 10855792,15215856 Component
7415 GO:0010494 IDA located_in cytoplasmic stress granule 29804830 Component
7415 GO:0032991 IDA part_of protein-containing complex 21822278,23349634 Component
7415 GO:0034098 IPI part_of VCP-NPL4-UFD1 AAA ATPase complex 20414249 Component
7415 GO:0035861 IDA located_in site of double-strand break 22120668 Component
7415 GO:0036513 IDA part_of Derlin-1 retrotranslocation complex 15215856,17872946 Component
7415 GO:0048471 IDA located_in perinuclear region of cytoplasm 16275660 Component
7415 GO:0070062 HDA located_in extracellular exosome 19056867,20458337,23533145 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
7415 GO:0003723 HDA enables RNA binding 22681889 Function
7415 GO:0005515 IPI enables protein binding 9452483,10364224,10855792,15161933,15215856,15743842,16186510,..... Function
7415 GO:0016887 IDA enables ATP hydrolysis activity 24129571 Function
7415 GO:0016887 IMP enables ATP hydrolysis activity 23349634 Function
7415 GO:0019903 IPI enables protein phosphatase binding 10364224 Function
7415 GO:0019904 IPI enables protein domain specific binding 15362974 Function
7415 GO:0031593 IDA enables polyubiquitin modification-dependent protein binding 11483959 Function
7415 GO:0031625 IPI enables ubiquitin protein ligase binding 22590560 Function
7415 GO:0035800 IDA enables deubiquitinase activator activity 22970133 Function
7415 GO:0042802 IPI enables identical protein binding 20512113,24055316,26712278,26822609,26849035 Function
7415 GO:0044389 IPI enables ubiquitin-like protein ligase binding 16186510 Function
7415 GO:0140036 IDA enables ubiquitin-dependent protein binding 35013556 Function
7415 GO:1904288 IPI enables BAT3 complex binding 21636303 Function
7415 GO:1990381 IPI enables ubiquitin-specific protease binding 22590560,22970133 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
7415 GO:0006302 IDA involved_in double-strand break repair 10855792,22120668 Process
7415 GO:0006734 IMP involved_in NADH metabolic process 23498975 Process
7415 GO:0006914 IMP involved_in autophagy 20104022,25125609 Process
7415 GO:0006974 IDA involved_in DNA damage response 16140914,22120668,23042605 Process
7415 GO:0010498 IMP involved_in proteasomal protein catabolic process 26565908 Process
7415 GO:0010918 IMP involved_in positive regulation of mitochondrial membrane potential 23498975 Process
7415 GO:0016236 IMP involved_in macroautophagy 27753622 Process
7415 GO:0016567 IDA involved_in protein ubiquitination 22120668 Process
7415 GO:0019079 IMP involved_in viral genome replication 22379090 Process
7415 GO:0019985 IMP involved_in translesion synthesis 23042605 Process
7415 GO:0030433 IDA involved_in ubiquitin-dependent ERAD pathway 17872946 Process
7415 GO:0030433 IMP involved_in ubiquitin-dependent ERAD pathway 22607976 Process
7415 GO:0030970 IDA involved_in retrograde protein transport, ER to cytosol 15215856 Process
7415 GO:0030970 IMP involved_in retrograde protein transport, ER to cytosol 25660456 Process
7415 GO:0031334 IDA involved_in positive regulation of protein-containing complex assembly 18775313 Process
7415 GO:0032436 IDA involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process 9452483 Process
7415 GO:0032510 IMP involved_in endosome to lysosome transport via multivesicular body sorting pathway 21822278 Process
7415 GO:0034605 IMP involved_in cellular response to heat 29804830 Process
7415 GO:0035617 IMP involved_in stress granule disassembly 29804830 Process
7415 GO:0036503 IDA involved_in ERAD pathway 24129571,25088257 Process
7415 GO:0036503 IMP involved_in ERAD pathway 20104022 Process
7415 GO:0043161 IMP involved_in proteasome-mediated ubiquitin-dependent protein catabolic process 20104022 Process
7415 GO:0045732 IDA involved_in positive regulation of protein catabolic process 11483959,18775313 Process
7415 GO:0045879 IMP involved_in negative regulation of smoothened signaling pathway 23747190 Process
7415 GO:0061857 IMP involved_in endoplasmic reticulum stress-induced pre-emptive quality control 26565908 Process
7415 GO:0071712 IMP involved_in ER-associated misfolded protein catabolic process 24089527 Process
7415 GO:0072389 IMP involved_in flavin adenine dinucleotide catabolic process 23498975 Process
7415 GO:0090263 IDA involved_in positive regulation of canonical Wnt signaling pathway 28689657 Process
7415 GO:0097352 IMP involved_in autophagosome maturation 20104022 Process
7415 GO:0106300 IDA involved_in protein-DNA covalent cross-linking repair 32152270 Process
7415 GO:0120186 IDA involved_in negative regulation of protein localization to chromatin 35013556 Process
7415 GO:1903006 IDA involved_in positive regulation of protein K63-linked deubiquitination 22970133 Process
7415 GO:1903007 IDA involved_in positive regulation of Lys63-specific deubiquitinase activity 22970133 Process
7415 GO:1903715 IMP involved_in regulation of aerobic respiration 23498975 Process
7415 GO:1903843 IMP involved_in cellular response to arsenite ion 29804830 Process
7415 GO:1903862 IMP involved_in positive regulation of oxidative phosphorylation 23498975 Process
7415 GO:1905634 IDA involved_in regulation of protein localization to chromatin 32152270 Process
7415 GO:2001171 IMP involved_in positive regulation of ATP biosynthetic process 23498975 Process