Gene Ontology

Gene Info

• Species:Human (Homo sapiens)
• GeneID:7486
• Symbol:WRN
• Description:WRN RecQ like helicase

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
7486	GO:0000287	IDA	enables	magnesium ion binding	16622405	Function
7486	GO:0000400	IDA	enables	four-way junction DNA binding	11735402	Function
7486	GO:0000403	IDA	enables	Y-form DNA binding	11735402,17715146,26420422	Function
7486	GO:0000405	IDA	enables	bubble DNA binding	11433031,11735402	Function
7486	GO:0003677	IDA	enables	DNA binding	9288107	Function
7486	GO:0003678	IDA	enables	DNA helicase activity	9288107,12181313,12944467,15200954,19734539,26420422.....	Function
7486	GO:0003678	IMP	enables	DNA helicase activity	10871376	Function
7486	GO:0004527	IDA	enables	exonuclease activity	12944467	Function
7486	GO:0004527	IMP	enables	exonuclease activity	15200954	Function
7486	GO:0005515	IPI	enables	protein binding	10373438,10783163,11328876,11427532,11598021,11919194,12181313.....	Function
7486	GO:0008408	IDA	enables	3'-5' exonuclease activity	10783163,10871373,12181313,16622405	Function
7486	GO:0009378	IDA	enables	four-way junction helicase activity	11433031,11735402	Function
7486	GO:0016887	IDA	enables	ATP hydrolysis activity	10373438,10871376	Function
7486	GO:0030145	IDA	enables	manganese ion binding	16622405	Function
7486	GO:0032405	IDA	enables	MutLalpha complex binding	17715146	Function
7486	GO:0042803	IDA	enables	protein homodimerization activity	10783163	Function
7486	GO:0043138	IDA	enables	3'-5' DNA helicase activity	17715146	Function
7486	GO:0044877	IDA	enables	protein-containing complex binding	10783163	Function
7486	GO:0051880	IDA	enables	G-quadruplex DNA binding	11433031,11735402	Function
7486	GO:0061749	IDA	enables	forked DNA-dependent helicase activity	11735402	Function
7486	GO:0061821	IDA	enables	telomeric D-loop binding	19734539,26420422	Function
7486	GO:0061849	IDA	enables	telomeric G-quadruplex DNA binding	19734539	Function
7486	GO:0070337	IDA	enables	3'-flap-structured DNA binding	26420422	Function
7486	GO:1905773	IDA	enables	8-hydroxy-2'-deoxyguanosine DNA binding	19734539	Function

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
7486	GO:0000723	IMP	involved_in	telomere maintenance	18212065	Process
7486	GO:0000731	IDA	involved_in	DNA synthesis involved in DNA repair	17563354	Process
7486	GO:0006259	IDA	involved_in	DNA metabolic process	16622405	Process
7486	GO:0006260	IMP	involved_in	DNA replication	12882351	Process
7486	GO:0006284	IDA	involved_in	base-excision repair	17611195	Process
7486	GO:0006302	IMP	involved_in	double-strand break repair	21639834	Process
7486	GO:0006974	IDA	involved_in	DNA damage response	18203716	Process
7486	GO:0006979	IDA	involved_in	response to oxidative stress	17611195	Process
7486	GO:0009267	IDA	acts_upstream_of_or_within	cellular response to starvation	11420665	Process
7486	GO:0010225	IDA	involved_in	response to UV-C	17563354	Process
7486	GO:0031297	IDA	involved_in	replication fork processing	17115688	Process
7486	GO:0031297	IMP	involved_in	replication fork processing	12882351	Process
7486	GO:0032508	IDA	involved_in	DNA duplex unwinding	11735402,26420422	Process
7486	GO:0044806	IDA	involved_in	G-quadruplex DNA unwinding	11735402	Process
7486	GO:0051345	IDA	involved_in	positive regulation of hydrolase activity	17611195	Process
7486	GO:0061820	IDA	involved_in	telomeric D-loop disassembly	15200954,19734539,26420422	Process
7486	GO:0061820	IGI	involved_in	telomeric D-loop disassembly	22039056	Process
7486	GO:0071480	IDA	involved_in	cellular response to gamma radiation	21639834	Process
7486	GO:0090398	IMP	involved_in	cellular senescence	18212065	Process
7486	GO:0098530	IDA	involved_in	positive regulation of strand invasion	26420422	Process
7486	GO:1902570	IDA	acts_upstream_of_or_within	protein localization to nucleolus	11420665	Process

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
7486	GO:0000781	IDA	located_in	chromosome, telomeric region	15200954,26420422	Component
7486	GO:0005654	IDA	located_in	nucleoplasm	11420665,12944467,17498979,21639834,25801465	Component
7486	GO:0005730	IDA	located_in	nucleolus	9618508,11420665,12181313,12944467,15200954,17498979,21639834,.....	Component
7486	GO:0005813	IDA	located_in	centrosome	17498979	Component
7486	GO:0016607	IDA	located_in	nuclear speck		Component