Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:7852
  • Symbol:CXCR4
  • Description:C-X-C motif chemokine receptor 4

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
7852 GO:0001666 IEP involved_in response to hypoxia 15174142 Process
7852 GO:0007186 IDA involved_in G protein-coupled receptor signaling pathway 10644702 Process
7852 GO:0019722 IMP acts_upstream_of_or_within calcium-mediated signaling 19064997 Process
7852 GO:0030155 IDA involved_in regulation of cell adhesion 19703720 Process
7852 GO:0030335 IMP involved_in positive regulation of cell migration 20023705 Process
7852 GO:0038160 IDA involved_in CXCL12-activated CXCR4 signaling pathway 28978524 Process
7852 GO:0038160 IMP involved_in CXCL12-activated CXCR4 signaling pathway 24912431 Process
7852 GO:0050920 IMP involved_in regulation of chemotaxis 19106094 Process
7852 GO:0071345 IDA involved_in cellular response to cytokine stimulus 21540189 Process
7852 GO:2000448 IMP involved_in positive regulation of macrophage migration inhibitory factor signaling pathway 19665027 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
7852 GO:0003779 IDA enables actin binding 12421915 Function
7852 GO:0005515 IPI enables protein binding 10644702,12421915,15660419,17077324,18632580,18765807,19106094..... Function
7852 GO:0019957 IPI enables C-C chemokine binding 25612609 Function
7852 GO:0031625 IPI enables ubiquitin protein ligase binding 19116316 Function
7852 GO:0032027 IDA enables myosin light chain binding 12421915 Function
7852 GO:0038147 IDA enables C-X-C motif chemokine 12 receptor activity 28978524 Function
7852 GO:0043130 IDA enables ubiquitin binding 20228059 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
7852 GO:0005764 IDA colocalizes_with lysosome 24790097 Component
7852 GO:0005764 IDA located_in lysosome 21540189 Component
7852 GO:0005769 IDA colocalizes_with early endosome 24790097 Component
7852 GO:0005769 IDA located_in early endosome 21540189 Component
7852 GO:0005770 IDA located_in late endosome 21540189 Component
7852 GO:0005886 IDA located_in plasma membrane 19665027,21540189 Component
7852 GO:0009986 IDA located_in cell surface 10521508,10644702,18308860,19106094,19665027,23620790..... Component
7852 GO:0031252 IDA located_in cell leading edge 12421915 Component
7852 GO:0031410 IDA located_in cytoplasmic vesicle 10521508,19106094 Component
7852 GO:0032991 IDA part_of protein-containing complex 19665027 Component
7852 GO:0032991 IMP part_of protein-containing complex 25612609 Component
7852 GO:0070062 HDA located_in extracellular exosome 20458337 Component