Gene Ontology

Gene Info

• Species:Mouse (Mus musculus)
• GeneID:78943
• Symbol:Ern1
• Description:endoplasmic reticulum (ER) to nucleus signalling 1

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
78943	GO:0004519	IDA	enables	endonuclease activity	11850408	Function
78943	GO:0004521	IDA	enables	RNA endonuclease activity	15601821,25164867	Function
78943	GO:0004674	IDA	enables	protein serine/threonine kinase activity	25164867	Function
78943	GO:0005515	IPI	enables	protein binding	16680093,18281285,19135427,19328063,23942232	Function
78943	GO:0042803	IDA	enables	protein homodimerization activity	25164867	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
78943	GO:0005637	IDA	located_in	nuclear inner membrane	11850408	Component
78943	GO:0005739	IDA	located_in	mitochondrion	23028046	Component
78943	GO:0005789	IDA	located_in	endoplasmic reticulum membrane	9755171	Component
78943	GO:1990597	IPI	part_of	AIP1-IRE1 complex	18281285	Component

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
78943	GO:0030968	IDA	acts_upstream_of_or_within	endoplasmic reticulum unfolded protein response	10882126,11430819,15601821	Process
78943	GO:0033120	IDA	involved_in	positive regulation of RNA splicing	25164867	Process
78943	GO:0036498	IDA	involved_in	IRE1-mediated unfolded protein response	24508390,25164867	Process
78943	GO:0043507	IMP	involved_in	positive regulation of JUN kinase activity	10650002	Process
78943	GO:0046777	IDA	acts_upstream_of_or_within	protein autophosphorylation	11430819	Process
78943	GO:0046777	IDA	involved_in	protein autophosphorylation	25164867	Process
78943	GO:0070059	IDA	acts_upstream_of_or_within	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	11146108	Process
78943	GO:0070059	IMP	involved_in	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	19328063	Process