Gene Ontology

Gene Info

• Species:Human (Homo sapiens)
• GeneID:834
• Symbol:CASP1
• Description:caspase 1

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
834	GO:0004175	IDA	enables	endopeptidase activity	24548080	Function
834	GO:0004197	IDA	enables	cysteine-type endopeptidase activity	1574116,2787508,11821383,15326478,16920334,22464733,32109412,3.....	Function
834	GO:0004197	IGI	enables	cysteine-type endopeptidase activity	15882992	Function
834	GO:0005515	IPI	enables	protein binding	11374873,11390368,11432859,11536016,12888622,15030775,15107016.....	Function
834	GO:0019900	IPI	enables	kinase binding	11432859,11536016,15383541	Function
834	GO:0042802	IMP	enables	identical protein binding	11432859	Function
834	GO:0042802	IPI	enables	identical protein binding	24630722,27043298	Function
834	GO:0050700	IPI	enables	CARD domain binding	11821383,16920334	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
834	GO:0005737	IDA	is_active_in	cytoplasm	20197547	Component
834	GO:0005829	IDA	is_active_in	cytosol	20197547	Component
834	GO:0032991	IDA	part_of	protein-containing complex	16920334	Component
834	GO:0032991	IMP	part_of	protein-containing complex	11536016,11821383,15383541	Component
834	GO:0061702	IPI	part_of	canonical inflammasome complex	16037825	Component
834	GO:0072558	IDA	part_of	NLRP1 inflammasome complex	12191486	Component
834	GO:0072558	IPI	part_of	NLRP1 inflammasome complex	17349957	Component
834	GO:0072559	IDA	part_of	NLRP3 inflammasome complex	15030775	Component
834	GO:0072559	IPI	part_of	NLRP3 inflammasome complex	29255148	Component
834	GO:0097169	IDA	part_of	AIM2 inflammasome complex	19158676	Component
834	GO:0097169	IPI	part_of	AIM2 inflammasome complex	24630722	Component
834	GO:0097179	IMP	part_of	protease inhibitor complex	11432859	Component

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
834	GO:0006508	IDA	involved_in	proteolysis	12888622,24548080	Process
834	GO:0016540	IDA	involved_in	protein autoprocessing	11821383,32109412	Process
834	GO:0032731	IDA	involved_in	positive regulation of interleukin-1 beta production	7642516,11432859,11821383,15326478,16037825,24630722.....	Process
834	GO:0032731	IMP	involved_in	positive regulation of interleukin-1 beta production	11536016,22267217	Process
834	GO:0032741	IDA	involved_in	positive regulation of interleukin-18 production	15326478	Process
834	GO:0043123	IEP	involved_in	positive regulation of I-kappaB kinase/NF-kappaB signaling	12761501	Process
834	GO:0043123	IMP	involved_in	positive regulation of I-kappaB kinase/NF-kappaB signaling	15383541	Process
834	GO:0043280	IMP	involved_in	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	16920334	Process
834	GO:0050727	IDA	involved_in	regulation of inflammatory response	32109412,32553275	Process
834	GO:0050729	IDA	involved_in	positive regulation of inflammatory response	12191486,15326478,32109412,32553275	Process
834	GO:0051604	IDA	involved_in	protein maturation	15326478,22464733,32109412,32553275	Process
834	GO:0070269	IDA	involved_in	pyroptosis	32109412,32553275	Process
834	GO:0071222	IDA	involved_in	cellular response to lipopolysaccharide	22464733	Process
834	GO:0071222	IMP	involved_in	cellular response to lipopolysaccharide	11536016	Process
834	GO:0071260	IEP	involved_in	cellular response to mechanical stimulus	19593445	Process
834	GO:0071310	IDA	acts_upstream_of_or_within	cellular response to organic substance	19158679	Process
834	GO:0071346	IMP	involved_in	cellular response to type II interferon	11536016	Process
834	GO:0140447	IGI	involved_in	cytokine precursor processing	15882992	Process
834	GO:0140448	IGI	involved_in	signaling receptor ligand precursor processing	15882992	Process
834	GO:0140970	IDA	involved_in	AIM2 inflammasome complex assembly	19158675	Process
834	GO:1903265	IMP	involved_in	positive regulation of tumor necrosis factor-mediated signaling pathway	16920334	Process