Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:837
  • Symbol:CASP4
  • Description:caspase 4

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
837 GO:0001530 IDA enables lipopolysaccharide binding 25119034 Function
837 GO:0004197 IDA enables cysteine-type endopeptidase activity 16920334,26375003,32109412,34671164 Function
837 GO:0005515 IPI enables protein binding 29077095,30692621 Function
837 GO:0050700 IPI enables CARD domain binding 16920334 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
837 GO:0005739 IDA located_in mitochondrion 15123740 Component
837 GO:0005783 IDA located_in endoplasmic reticulum 15123740 Component
837 GO:0005829 IDA is_active_in cytosol 23661706 Component
837 GO:0005829 IDA located_in cytosol Component
837 GO:0005886 IDA located_in plasma membrane Component
837 GO:0032991 IDA part_of protein-containing complex 16920334 Component
837 GO:0160074 IDA part_of non-canonical inflammasome complex 25119034,31268602 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
837 GO:0016540 IDA involved_in protein autoprocessing 32109412,34671164 Process
837 GO:0042742 IDA involved_in defense response to bacterium 25119034 Process
837 GO:0050727 IDA involved_in regulation of inflammatory response 32109412 Process
837 GO:0050729 IDA involved_in positive regulation of inflammatory response 33377178,34671164 Process
837 GO:0050830 IDA involved_in defense response to Gram-positive bacterium 33377178 Process
837 GO:0051604 IDA involved_in protein maturation 25119034,26375003,34671164 Process
837 GO:0070059 IMP involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 15123740 Process
837 GO:0070269 IDA involved_in pyroptosis 31268602,32109412,34671164 Process
837 GO:0097193 IMP involved_in intrinsic apoptotic signaling pathway 15123740 Process
837 GO:0160075 IDA involved_in non-canonical inflammasome complex assembly 25119034,26375003,31268602,34671164 Process
837 GO:1903265 IDA involved_in positive regulation of tumor necrosis factor-mediated signaling pathway 16920334 Process
837 GO:1904646 IMP involved_in cellular response to amyloid-beta 15123740 Process
837 GO:2000494 IDA involved_in positive regulation of interleukin-18-mediated signaling pathway 33377178 Process