Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:841
  • Symbol:CASP8
  • Description:caspase 8

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
841 GO:0004197 IDA enables cysteine-type endopeptidase activity 16920334,19240112,33852854,35594856 Function
841 GO:0005515 IPI enables protein binding 9208847,9334338,9343261,9560245,10442631,12198154,12884866,128..... Function
841 GO:0008233 IDA enables peptidase activity 19740745 Function
841 GO:0008233 IMP enables peptidase activity 17047155 Function
841 GO:0031625 IPI enables ubiquitin protein ligase binding 15069192 Function
841 GO:0035877 IPI enables death effector domain binding 11717445 Function
841 GO:0042802 IPI enables identical protein binding 16169070,17170703 Function
841 GO:0097110 IPI enables scaffold protein binding 21785459 Function
841 GO:0097153 IDA enables cysteine-type endopeptidase activity involved in apoptotic process 16916640,31827280 Function
841 GO:0097153 IMP enables cysteine-type endopeptidase activity involved in apoptotic process 21737330 Function
841 GO:0097199 IDA enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway 16916640,16920334 Function
841 GO:0097199 IMP enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway 11717445,21980415 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
841 GO:0005654 IDA located_in nucleoplasm Component
841 GO:0005737 IDA is_active_in cytoplasm 17167422 Component
841 GO:0005829 IDA located_in cytosol 17167422 Component
841 GO:0031264 IDA part_of death-inducing signaling complex 11101870,21803845 Component
841 GO:0031265 IDA part_of CD95 death-inducing signaling complex 11717445 Component
841 GO:0032991 IDA part_of protein-containing complex 22267217 Component
841 GO:0097342 IDA part_of ripoptosome 21737330 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
841 GO:0006508 IDA involved_in proteolysis 12888622 Process
841 GO:0006915 IMP involved_in apoptotic process 22891283 Process
841 GO:0006919 IDA involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process 16916640 Process
841 GO:0032731 IMP involved_in positive regulation of interleukin-1 beta production 22267217 Process
841 GO:0034612 IMP involved_in response to tumor necrosis factor 10521396 Process
841 GO:0036462 IDA involved_in TRAIL-activated apoptotic signaling pathway 21785459 Process
841 GO:0043123 IEP involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling 12761501 Process
841 GO:0043123 IMP involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling 12884866 Process
841 GO:0043124 IMP involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling 17047155 Process
841 GO:0045651 IMP involved_in positive regulation of macrophage differentiation 17047155 Process
841 GO:0045862 IDA involved_in positive regulation of proteolysis 18387192 Process
841 GO:0051603 IMP involved_in proteolysis involved in protein catabolic process 10521396 Process
841 GO:0051604 IDA involved_in protein maturation 16916640,33852854,35594856 Process
841 GO:0060546 IDA involved_in negative regulation of necroptotic process 31827280 Process
841 GO:0071260 IEP involved_in cellular response to mechanical stimulus 19593445 Process
841 GO:0097190 IMP involved_in apoptotic signaling pathway 11101870 Process
841 GO:0097191 IDA involved_in extrinsic apoptotic signaling pathway 21785459,35446120 Process
841 GO:0097194 IMP involved_in execution phase of apoptosis 21737330 Process
841 GO:0097202 IDA involved_in activation of cysteine-type endopeptidase activity 18387192 Process