Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:8767
  • Symbol:RIPK2
  • Description:receptor interacting serine/threonine kinase 2

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
8767 GO:0005102 IPI enables signaling receptor binding 24790089 Function
8767 GO:0005515 IPI enables protein binding 11432859,11536016,15383541,16418290,19337385,19667203,21887730..... Function
8767 GO:0030274 IPI enables LIM domain binding 15657077 Function
8767 GO:0035591 IDA enables signaling adaptor activity 16824733,29452636,30026309,30279485,30478312 Function
8767 GO:0042802 IPI enables identical protein binding 25416956,32296183 Function
8767 GO:0042803 IDA enables protein homodimerization activity 19337385 Function
8767 GO:0050700 IDA enables CARD domain binding 10329646 Function
8767 GO:0050700 IPI enables CARD domain binding 11087742 Function
8767 GO:0089720 IPI enables caspase binding 11432859,11536016,15383541 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
8767 GO:0005737 IDA located_in cytoplasm 21887730 Component
8767 GO:0005829 IDA located_in cytosol Component
8767 GO:0005856 IDA located_in cytoskeleton 21887730 Component
8767 GO:0005886 IDA is_active_in plasma membrane 17355968 Component
8767 GO:0031982 IDA located_in vesicle 21887730 Component
8767 GO:0032991 IDA part_of protein-containing complex 11536016,15383541,21887730 Component
8767 GO:0032991 IMP part_of protein-containing complex 11432859 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
8767 GO:0006915 IDA involved_in apoptotic process 16920334 Process
8767 GO:0010800 IDA involved_in positive regulation of peptidyl-threonine phosphorylation 21887730 Process
8767 GO:0031398 IMP involved_in positive regulation of protein ubiquitination 15620648 Process
8767 GO:0032092 IMP involved_in positive regulation of protein binding 11432859 Process
8767 GO:0032731 IDA involved_in positive regulation of interleukin-1 beta production 11432859 Process
8767 GO:0033138 IDA involved_in positive regulation of peptidyl-serine phosphorylation 21887730 Process
8767 GO:0034134 IDA acts_upstream_of_or_within toll-like receptor 2 signaling pathway 11894098 Process
8767 GO:0042742 IDA involved_in defense response to bacterium 16824733 Process
8767 GO:0043123 IDA acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling 10329646 Process
8767 GO:0045087 IDA involved_in innate immune response 23806334 Process
8767 GO:0050731 IDA involved_in positive regulation of peptidyl-tyrosine phosphorylation 21887730 Process
8767 GO:0051092 IDA involved_in positive regulation of NF-kappaB transcription factor activity 11821383,29452636,30026309,30279485,30478312 Process
8767 GO:0051092 IMP involved_in positive regulation of NF-kappaB transcription factor activity 21887730,21931591 Process
8767 GO:0051260 IDA involved_in protein homooligomerization 30279485,30478312 Process
8767 GO:0070427 IDA involved_in nucleotide-binding oligomerization domain containing 1 signaling pathway 30279485 Process
8767 GO:0070431 IDA involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway 16824733,17355968,17562858,23806334,28545134,29452636,30026309..... Process
8767 GO:0071225 IDA involved_in cellular response to muramyl dipeptide 21887730 Process
8767 GO:0097202 IDA involved_in activation of cysteine-type endopeptidase activity 11821383 Process
8767 GO:1902523 IDA involved_in positive regulation of protein K63-linked ubiquitination 17562858 Process