Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:8837
  • Symbol:CFLAR
  • Description:CASP8 and FADD like apoptosis regulator

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
8837 GO:0002020 IPI enables protease binding 9208847 Function
8837 GO:0005515 IPI enables protein binding 9208847,11741985,12887920,17047155,23541952,24438025,25241761,..... Function
8837 GO:0008047 IDA enables enzyme activator activity 9208847 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
8837 GO:0005737 IDA located_in cytoplasm 18073330 Component
8837 GO:0031264 IDA part_of death-inducing signaling complex 21803845 Component
8837 GO:0097342 IDA part_of ripoptosome 21737330 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
8837 GO:0006915 IMP involved_in apoptotic process 21737330 Process
8837 GO:0043123 IEP involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling 12761501 Process
8837 GO:0060544 IDA involved_in regulation of necroptotic process 21737330 Process
8837 GO:1902042 IDA acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 26582200 Process
8837 GO:1902042 IMP involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 18202225 Process
8837 GO:2001237 IDA involved_in negative regulation of extrinsic apoptotic signaling pathway 9208847 Process
8837 GO:2001237 IMP involved_in negative regulation of extrinsic apoptotic signaling pathway 22266862 Process