Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:9025
  • Symbol:RNF8
  • Description:ring finger protein 8

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
9025 GO:0000151 IDA part_of ubiquitin ligase complex 18001824,18001825 Component
9025 GO:0005634 IDA located_in nucleus 18001824,18001825 Component
9025 GO:0005654 IDA located_in nucleoplasm Component
9025 GO:0005829 IDA located_in cytosol Component
9025 GO:0035861 IDA located_in site of double-strand break 22266820 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
9025 GO:0003682 IDA enables chromatin binding 18001824,18001825 Function
9025 GO:0004842 IDA enables ubiquitin-protein transferase activity 18001824,18001825,18948756,21911360,22266820,22373579,22980979..... Function
9025 GO:0005515 IPI enables protein binding 16189514,18001824,18001825,19690564,20023648,21516116,22266820..... Function
9025 GO:0008270 IDA enables zinc ion binding 22980979 Function
9025 GO:0031625 IPI enables ubiquitin protein ligase binding 22266820 Function
9025 GO:0042393 IDA enables histone binding 18001824,18001825 Function
9025 GO:0042802 IPI enables identical protein binding 22980979,32296183 Function
9025 GO:0042803 IDA enables protein homodimerization activity 22980979 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
9025 GO:0006302 IDA involved_in double-strand break repair 18001824,18001825,22980979 Process
9025 GO:0006511 IDA involved_in ubiquitin-dependent protein catabolic process 22266820,22373579 Process
9025 GO:0006974 IDA involved_in DNA damage response 20550933,21911360,22266820,22373579,22980979 Process
9025 GO:0010212 IDA involved_in response to ionizing radiation 18001824,18001825 Process
9025 GO:0034244 IMP involved_in negative regulation of transcription elongation by RNA polymerase II 20550933 Process
9025 GO:0040029 IMP involved_in epigenetic regulation of gene expression 20550933 Process
9025 GO:0045739 IDA involved_in positive regulation of DNA repair 18001824,18001825 Process
9025 GO:0051865 IDA involved_in protein autoubiquitination 22266820 Process
9025 GO:0070534 IDA involved_in protein K63-linked ubiquitination 21911360 Process
9025 GO:0070936 IDA involved_in protein K48-linked ubiquitination 21911360,22266820,22373579 Process
9025 GO:0140861 IDA involved_in DNA repair-dependent chromatin remodeling 18001824,18001825,22980979 Process