Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:9353
  • Symbol:SLIT2
  • Description:slit guidance ligand 2

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
9353 GO:0001657 IMP involved_in ureteric bud development 15130495 Process
9353 GO:0001933 IDA involved_in negative regulation of protein phosphorylation 18345009 Process
9353 GO:0002042 IMP involved_in cell migration involved in sprouting angiogenesis 19351956 Process
9353 GO:0002689 IDA involved_in negative regulation of leukocyte chemotaxis 11309622 Process
9353 GO:0007411 IDA involved_in axon guidance 11748139 Process
9353 GO:0008045 IDA involved_in motor neuron axon guidance 10102268 Process
9353 GO:0010593 IDA involved_in negative regulation of lamellipodium assembly 16439689 Process
9353 GO:0010596 IDA involved_in negative regulation of endothelial cell migration 18345009 Process
9353 GO:0014912 IDA involved_in negative regulation of smooth muscle cell migration 16439689 Process
9353 GO:0021834 IDA NOT involved_in chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration 11748139 Process
9353 GO:0021836 IDA involved_in chemorepulsion involved in postnatal olfactory bulb interneuron migration 15207848 Process
9353 GO:0021972 IMP involved_in corticospinal neuron axon guidance through spinal cord 10975526 Process
9353 GO:0030308 IMP involved_in negative regulation of cell growth 18829537 Process
9353 GO:0030336 IDA involved_in negative regulation of cell migration 19005219 Process
9353 GO:0030336 IMP involved_in negative regulation of cell migration 18566128 Process
9353 GO:0030837 IDA involved_in negative regulation of actin filament polymerization 19759280 Process
9353 GO:0031290 IDA involved_in retinal ganglion cell axon guidance 10864954,19498462 Process
9353 GO:0032870 IEP involved_in cellular response to hormone stimulus 18566128 Process
9353 GO:0035385 IMP involved_in Roundabout signaling pathway 18829537 Process
9353 GO:0043065 IMP involved_in positive regulation of apoptotic process 18566128 Process
9353 GO:0043116 IDA involved_in negative regulation of vascular permeability 18345009 Process
9353 GO:0048754 IDA involved_in branching morphogenesis of an epithelial tube 18345009 Process
9353 GO:0048754 IMP involved_in branching morphogenesis of an epithelial tube 19005219 Process
9353 GO:0048846 IDA involved_in axon extension involved in axon guidance 16840550 Process
9353 GO:0050919 IDA involved_in negative chemotaxis 11748139 Process
9353 GO:0050919 IMP involved_in negative chemotaxis 19005219 Process
9353 GO:0050929 IDA involved_in induction of negative chemotaxis 10197527 Process
9353 GO:0051058 IDA involved_in negative regulation of small GTPase mediated signal transduction 16439689 Process
9353 GO:0051414 IEP involved_in response to cortisol 18566128 Process
9353 GO:0061364 IEP involved_in apoptotic process involved in luteolysis 18566128 Process
9353 GO:0070100 IMP involved_in negative regulation of chemokine-mediated signaling pathway 18829537 Process
9353 GO:0071504 IDA involved_in cellular response to heparin 17062560 Process
9353 GO:0071672 IDA involved_in negative regulation of smooth muscle cell chemotaxis 16439689 Process
9353 GO:0071676 IDA involved_in negative regulation of mononuclear cell migration 16439689 Process
9353 GO:0090024 IDA involved_in negative regulation of neutrophil chemotaxis 19759280 Process
9353 GO:0090260 IDA involved_in negative regulation of retinal ganglion cell axon guidance 17062560 Process
9353 GO:0090288 IDA involved_in negative regulation of cellular response to growth factor stimulus 16439689 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
9353 GO:0005095 IDA enables GTPase inhibitor activity 16439689,19759280 Function
9353 GO:0005515 IPI enables protein binding 10102268,17848514 Function
9353 GO:0008201 IDA enables heparin binding 17062560 Function
9353 GO:0042802 IPI enables identical protein binding 19498462 Function
9353 GO:0042803 IDA enables protein homodimerization activity 19498462 Function
9353 GO:0043237 IDA enables laminin-1 binding 10102268 Function
9353 GO:0043394 IPI enables proteoglycan binding 11375980 Function
9353 GO:0048495 IPI enables Roundabout binding 10102268,15207848,17848514 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
9353 GO:0005615 IDA located_in extracellular space 16439689,19005219 Component
9353 GO:0005737 IDA located_in cytoplasm 18566128 Component
9353 GO:0070062 HDA located_in extracellular exosome 19056867 Component