Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:9475
  • Symbol:ROCK2
  • Description:Rho associated coiled-coil containing protein kinase 2

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
9475 GO:0001934 IMP involved_in positive regulation of protein phosphorylation 24065547 Process
9475 GO:0006468 IDA involved_in protein phosphorylation 18559669 Process
9475 GO:0007249 IMP involved_in I-kappaB kinase/NF-kappaB signaling 25816133 Process
9475 GO:0010595 IMP involved_in positive regulation of endothelial cell migration 24065547 Process
9475 GO:0010628 IMP involved_in positive regulation of gene expression 24065547 Process
9475 GO:0016525 IMP involved_in negative regulation of angiogenesis 19181962 Process
9475 GO:0018105 IMP involved_in peptidyl-serine phosphorylation 24305806 Process
9475 GO:0018107 IMP involved_in peptidyl-threonine phosphorylation 24305806,29353861 Process
9475 GO:0030335 IMP involved_in positive regulation of cell migration 20232393 Process
9475 GO:0030866 IGI involved_in cortical actin cytoskeleton organization 25816133 Process
9475 GO:0030866 IMP involved_in cortical actin cytoskeleton organization 25816133 Process
9475 GO:0035509 IGI involved_in negative regulation of myosin-light-chain-phosphatase activity 25816133 Process
9475 GO:0035509 IMP involved_in negative regulation of myosin-light-chain-phosphatase activity 25816133 Process
9475 GO:0044788 IMP involved_in modulation by host of viral process 19376974 Process
9475 GO:0045019 IMP involved_in negative regulation of nitric oxide biosynthetic process 29353861 Process
9475 GO:0045616 IMP involved_in regulation of keratinocyte differentiation 19997641 Process
9475 GO:0051298 IMP involved_in centrosome duplication 17015463 Process
9475 GO:0051496 IMP involved_in positive regulation of stress fiber assembly 20232393 Process
9475 GO:0071394 IMP involved_in cellular response to testosterone stimulus 24065547 Process
9475 GO:0072659 IGI involved_in protein localization to plasma membrane 25816133 Process
9475 GO:0072659 IMP involved_in protein localization to plasma membrane 25816133 Process
9475 GO:0150033 IMP involved_in negative regulation of protein localization to lysosome 24305806 Process
9475 GO:1902004 IMP involved_in positive regulation of amyloid-beta formation 24305806 Process
9475 GO:1902961 IMP involved_in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 24305806 Process
9475 GO:1902966 IMP involved_in positive regulation of protein localization to early endosome 24305806 Process
9475 GO:1902993 IMP involved_in positive regulation of amyloid precursor protein catabolic process 24305806 Process
9475 GO:1903140 IGI involved_in regulation of establishment of endothelial barrier 25816133 Process
9475 GO:1903140 IMP involved_in regulation of establishment of endothelial barrier 25816133 Process
9475 GO:1903347 IGI involved_in negative regulation of bicellular tight junction assembly 25816133 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
9475 GO:0003723 HDA enables RNA binding 22681889 Function
9475 GO:0004674 IDA enables protein serine/threonine kinase activity 16574662,21147781 Function
9475 GO:0004674 IMP enables protein serine/threonine kinase activity 24305806,29353861 Function
9475 GO:0005515 IPI enables protein binding 17015463,20230755,30413785,32814053 Function
9475 GO:0072518 IMP enables Rho-dependent protein serine/threonine kinase activity 24065547 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
9475 GO:0005813 IDA located_in centrosome 17015463 Component
9475 GO:0005829 IDA located_in cytosol Component
9475 GO:0036464 IDA located_in cytoplasmic ribonucleoprotein granule 15121898 Component