Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:9641
  • Symbol:IKBKE
  • Description:inhibitor of nuclear factor kappa B kinase subunit epsilon

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
9641 GO:0004674 EXP enables protein serine/threonine kinase activity 30420664 Function
9641 GO:0004674 IDA enables protein serine/threonine kinase activity 12692549 Function
9641 GO:0004704 IDA enables NF-kappaB-inducing kinase activity 10882136 Function
9641 GO:0005515 IPI enables protein binding 14743216,16177806,16281057,17568778,17599067,17600090,18636086..... Function
9641 GO:0031625 IPI enables ubiquitin protein ligase binding 24882218 Function
9641 GO:0036435 IMP enables K48-linked polyubiquitin modification-dependent protein binding 24882218 Function
9641 GO:0042802 IPI enables identical protein binding 24882218 Function
9641 GO:0070530 IMP NOT enables K63-linked polyubiquitin modification-dependent protein binding 24882218 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
9641 GO:0005634 IDA located_in nucleus 20188669 Component
9641 GO:0005737 IDA is_active_in cytoplasm 12692549 Component
9641 GO:0005737 IDA located_in cytoplasm 20188669,24882218 Component
9641 GO:0016605 IDA located_in PML body 20188669 Component
9641 GO:0031966 IMP located_in mitochondrial membrane 16876765 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
9641 GO:0006468 IDA involved_in protein phosphorylation 10882136,20188669,24882218 Process
9641 GO:0008630 IMP involved_in intrinsic apoptotic signaling pathway in response to DNA damage 20188669 Process
9641 GO:0032481 IDA involved_in positive regulation of type I interferon production 12692549 Process
9641 GO:0035456 IMP involved_in response to interferon-beta 24882218 Process
9641 GO:0043123 IEP involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling 12761501 Process
9641 GO:0051091 IMP involved_in positive regulation of DNA-binding transcription factor activity 26934326 Process
9641 GO:0060340 IDA involved_in positive regulation of type I interferon-mediated signaling pathway 24882218 Process