| 102626 | Q3UMW7 | MAPK3_MOUSE | MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) | DISRUPTION PHENOTYPE | No visible phenotype. Mice are fertile and do not exhibit behavioral phenotype. Mice do not show decreased production of inflammatory cytokines such as TNF and IL6 upon LPS-stimulation. Mice lacking both Mapkapk2 and Mapkapk3 show further reduction of TNF production, compared to mice lacking only Mapkapk2. These data suggest that Mapkapk3 may function additively in stress-induced cytokine production. MAPKAPK3 knockdown homozygous mice develop Bruch's membrane abnormal thickening and thinning progressing with age (PubMed:26744326). {ECO:0000269|PubMed:17030606, ECO:0000269|PubMed:26744326}. |