| 107831 | Q3UHD1 | AGRB1_MOUSE | Adhesion G protein-coupled receptor B1 (Brain-specific angiogenesis inhibitor 1) [Cleaved into: Vasculostatin-120 (Vstat120); Vasculostatin-40 (Vstat-40)] | DISRUPTION PHENOTYPE | Viable and fertile with normal brain anatomy but mutants display severe deficits in hippocampus-dependent spatial learning and memory that are accompanied by enhanced long-term potentiation, impaired long-term depression, a thinning of the postsynaptic density at hippocampal synapses, reduced protein levels of Dlg4 and increased Dlg4 polyubiquitination (PubMed:25751059). Smaller myofibers than wild-type animals and impaired muscle regeneration after injury (PubMed:23615608). Impaired bacterial clearance following E.coli infection (PubMed:26838550). RNAi-mediated knockdown in embryos results in greatly reduced dendritic spine density and small but significant increases in spine length and decreases in spine diameter (PubMed:23595754). {ECO:0000269|PubMed:23595754, ECO:0000269|PubMed:23615608, ECO:0000269|PubMed:25751059, ECO:0000269|PubMed:26838550}. |