| 107986 | Q99J79 | DDB2_MOUSE | DNA damage-binding protein 2 (Damage-specific DNA-binding protein 2) | DISRUPTION PHENOTYPE | Mice exhibit elevated susceptibility to UV-induced skin carcinogenesis and enhanced rates of spontaneous tumor formation, particularly for lung and mammary adenocarcinomas. DDB2 is haploinsufficient as a tumor suppressor. The spleens of these animals are enlarged due to enhanced lymphoid proliferation while the testes are also enlarged due to reduced rates of apoptosis of testicular germ cells. Fibroblasts from these animals are resistant to p53-dependent apoptosis induced by UV treatment. {ECO:0000269|PubMed:14769931, ECO:0000269|PubMed:15558025, ECO:0000269|PubMed:17468495}. |