| 109113 | Q7TMI3 | UHRF2_MOUSE | E3 ubiquitin-protein ligase UHRF2 (EC 2.3.2.27) (NIRF) (Np95-like ring finger protein) (Nuclear protein 97) (Nuclear zinc finger protein Np97) (RING-type E3 ubiquitin transferase UHRF2) (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubi | DISRUPTION PHENOTYPE | Deletion mice are viable, fertile, and grossly normal (PubMed:28402695, PubMed:28115522). However, adult mice develop frequent spontaneous seizures and display abnormal electrical activities in brain (PubMed:28402695). In addition, they display reduced 5-hydroxymethylcytosine (5hmC) in genomic DNA in the brain together with impaired spatial memory acquisition and retention (PubMed:28115522). {ECO:0000269|PubMed:28115522, ECO:0000269|PubMed:28402695}. |