| 109676 | Q8C8R3 | ANK2_MOUSE | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) | DISRUPTION PHENOTYPE | Heterozygous knockout mice exhibit bradycardia and show a high degree of heart-rate variability associated with multiple episodes of abrupt sinus slowing and show episodes of intermittent isorhythmic atrioventricular dissociation similar to rhythm disturbances. Over half of the mutant animals die after exercise combined with epinephrine (PubMed:12571597). Mutant animals display premature senescence and reduced longevity (PubMed:17940615). {ECO:0000269|PubMed:12571597, ECO:0000269|PubMed:17940615}. |