110876 | B1AWN6 | SCN2A_MOUSE | Sodium channel protein type 2 subunit alpha (Voltage-gated sodium channel subunit alpha Nav1.2) | DISRUPTION PHENOTYPE | Conditional knockout mice deficient in brain are morphologically and organogenically indistinguishable from their heterozygous littermates. They die perinatally with severe hypoxia and massive neuronal apoptosis, notably in the brainstem. Sodium channel currents recorded from cultured neurons of knockout mice are sharply attenuated. {ECO:0000269|PubMed:10827969}. |