| 11350 | P00520 | ABL1_MOUSE | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | DISRUPTION PHENOTYPE | Mutants are born with the expected Mendelian frequency, but fail to thrive and most die within three weeks after birth. Most mutants are runted, and have atrophied thymuses with severe thymocyte deficiency. Mutants that survive to weaning age are most often runted, and about half of them show lymphopenia. They display a major reduction in the number of pre-B and immature B-cell classes in bone marrow with a wide variation between individuals, but essentially normal mature B-cell levels. Mutants are highly susceptible to infections. T-cells show impaired directional migration in response to the chemokines Cxcl12 or Ccl21 (PubMed:22810897). Abl1 and Abl2 double knockout mice have T-cells that show reduced chemokinesis and cell polarization in response to Icam1, Cxcl12 and Ccl21, subsequent Rap1 and Rac1 activation is reduced (PubMed:22810897). Additionally T-cells show decreased Cxcl12-induced tyrosine phosphorylation of Nedd9/Hef1 and reduced homing of T-cells to lymph nodes and immuno-challenged tissues (PubMed:22810897). {ECO:0000269|PubMed:2065352, ECO:0000269|PubMed:2065353, ECO:0000269|PubMed:22810897}. |