| Gene ID | Entry | Entry Name | Protein Name | Type | Information | 114716 | Q924S7 | SPRE2_MOUSE | Sprouty-related, EVH1 domain-containing protein 2 (Spred-2) | DISRUPTION PHENOTYPE | SPRED2 knockout results in a dwarf phenotype characterized by reduced growth and body weight, shorter tibia length, and narrower growth plates as compared with wild-type mice. Mutant animals regularly develop kyphosis and scoliosis, and show craniofacial defects, splenomegaly, and cardiac hypertrophy with arrhythmias. {ECO:0000269|PubMed:15946934, ECO:0000269|PubMed:34626534}. |
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