| 11596 | Q62151 | RAGE_MOUSE | Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products) | DISRUPTION PHENOTYPE | In deletion mutant mice, the elevation of serum TNF-alpha, IL6 and EDN1 and the tissue damage induced by LPS is significantly attenuated when compared with WT mice (PubMed:21270403). The lower hepatic expression of pro-inflammatory cytokines, while the activation of immune cells remains unaffected, results in improved survival after challenge with D-galactosamine (PubMed:32670276). {ECO:0000269|PubMed:21270403, ECO:0000269|PubMed:32670276}. |