| 11658 | Q61490 | CD166_MOUSE | CD166 antigen (Activated leukocyte cell adhesion molecule) (BEN) (Protein DM-GRASP) (CD antigen CD166) | DISRUPTION PHENOTYPE | Mice are born at the expected Mendelian rate, are viable and fertile and display no obvious external phenotype. Unlike wild-type mice, that have tightly fasciculated and smooth nerve bundles, mutant mice have more loosely bundled nerves with many single axons extending out of the main nerve. Eyes from mutant mice display a variable degree of retinal displasia (PubMed:15345243). Besides, lymph nodes from mutant mice display reduced weight and cellularity, but appear otherwise normal (PubMed:23169771). Mutant mice have only half of the normal number of hematopoietic stem cells in their bone marrow (PubMed:24740813, PubMed:25730656). Survival of lethally irradiated mice that receive bone marrow from mutant mice is impaired, due to impaired homotypic cell-cell attachment, impaired engraftment and proliferation of mutant hematopoietic stem cells (PubMed:24740813). Mutant mice are larger and heavier than wild-type and have increased bone mineral density (PubMed:25730656). Mutant spleen has an altered leukocyte composition, with reduced numbers of CD4(+) and CD8(+) T-cells, B-cells, dendritic cells, neutrophils and macrophages, but no change in the total leukocyte number. Their lungs display reduced numbers of lymph vessel and blood vessel endothelial cells, but no difference in lung weight. Lymph vessels in mesentery and diaphragm are more densely interconnected and show a decreased level of hierarchical vascular organization in mutant mice (PubMed:23169771). {ECO:0000269|PubMed:15345243, ECO:0000269|PubMed:23169771, ECO:0000269|PubMed:25730656}. |