| 11699 | Q07456 | AMBP_MOUSE | Protein AMBP [Cleaved into: Alpha-1-microglobulin (EC 1.6.2.-); Inter-alpha-trypsin inhibitor light chain (ITI-LC) (Bikunin) (HI-30); Trypstatin] | DISRUPTION PHENOTYPE | [Alpha-1-microglobulin]: Mutant mice has normal litter size. At 12 months of age they show significant increase in body weight, which is partly due to fat accumulation in the liver with a subsequent increase in liver mass (PubMed:32092411). They display an abnormal red blood cell morphology, similar to macrocytic anemia characterized by fewer, larger and heterogeneous red cells (PubMed:32092412). {ECO:0000269|PubMed:32092411, ECO:0000269|PubMed:32092412}.; DISRUPTION PHENOTYPE: [Inter-alpha-trypsin inhibitor light chain]: Mice are born at the expected Mendelian rate. Mutant female mice show severe infertility due to impaired cumulus oophorus expansion upon gonadotropin surge. {ECO:0000269|PubMed:11145954, ECO:0000269|PubMed:11243855}. |