| 11944 | Q64436 | ATP4A_MOUSE | Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump) | DISRUPTION PHENOTYPE | Mutant mice are born at the expected Mendelian rate. They develop achlorhydria, hypergastrinemia and ciliated metaplasia. The parietal cell viability or chief cell differentiation are normal when compared to wild-type littermates. Mutant parietal cells have abnormal morphology characterized by dilated canaliculi with few microvilli, spherical vesicles rather than normal tubulovesicles and enlarged mitochondria filled with concentric cristae. {ECO:0000269|PubMed:10764766}. |