| 12153 | P98063 | BMP1_MOUSE | Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP) | DISRUPTION PHENOTYPE | Deletion mice are perinatally lethal, with the most obvious gross abnormality being failure of ventral body wall closure, and persistent herniation of the gut. This phenotype likely reflects the defective and weakened nature of extracellular matrix (ECM) in these embryos (PubMed:8951074). Double knockout mice (BMP1 and TLL1) display progressive defects in teeth and bone development (PubMed:28068493, PubMed:24419319). {ECO:0000269|PubMed:24419319, ECO:0000269|PubMed:28068493, ECO:0000269|PubMed:8951074}. |