| 12365 | O89094 | CASPE_MOUSE | Caspase-14 (CASP-14) (EC 3.4.22.-) (Mini-ICE) (MICE) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form] | DISRUPTION PHENOTYPE | Mice show a shiny and lichenified skin with an epidermis containing more alveolar keratohyalin F-granules and an altered profilaggrin processing. The skin is highly sensitive to the formation of cyclobutane pyrimidine dimers after UVB irradiation, leading to increased levels of UVB-induced apoptosis (PubMed:17515931). Mice accumulate incomplete filaggrin breakdown products within the epidermal stratum corneum (SC), leading to reduced levels of natural moisturizing factors (NMFs) and lower SC hydration (PubMed:21654840). {ECO:0000269|PubMed:17515931, ECO:0000269|PubMed:21654840}. |