| 12368 | O08738 | CASP6_MOUSE | Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11] | DISRUPTION PHENOTYPE | Casp6-knockout mice are grossly normal, breed with Mendelian ratio, and are only slightly protected from anti-Fas/CD95-induced cell death (PubMed:11062535). Casp6-deficient neurons undergo apoptosis and exhibit soma and axon degeneration just as wild type neurons (PubMed:23695670). While Casp6-deficiency is able to block axon degeneration with local deprivation, it is incapable of doing so with global deprivation (PubMed:23695670). In addition, B-cell differentiation into plasma cells is accelerated in deletion mutants compared to wild-type (PubMed:18981099, PubMed:29863787). Casp6-knockout mice are more susceptible to influenza virus infection (PubMed:32298652). {ECO:0000269|PubMed:11062535, ECO:0000269|PubMed:18981099, ECO:0000269|PubMed:23695670, ECO:0000269|PubMed:29863787, ECO:0000269|PubMed:32298652}. |