| 12369 | P97864 | CASP7_MOUSE | Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] | DISRUPTION PHENOTYPE | No visible phenotype; on the 129/Svj background, mice are healthy (PubMed:16469926). Mice display impaired lipopolysaccharide (LPS)-induced lymphocyte apoptosis and are markedly protected from LPS-induced lethality (PubMed:19168786). Mice lacking Casp3 and Casp7 on the C57BL/6J background die immediately after birth because of defective heart development (PubMed:16469926). {ECO:0000269|PubMed:16469926, ECO:0000269|PubMed:19168786}. |