| 12370 | O89110 | CASP8_MOUSE | Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] | DISRUPTION PHENOTYPE | Embryonic lethality at lethality at 10.5 dpc (PubMed:9729047). Embryos display impaired heart muscle development and congested accumulation of erythrocytes (PubMed:9729047). Perinatal lethality observed in Ripk1 knockout mice is rescued in knockout mice lacking both Ripk1 and Casp8; mice however die the first days of postnatal life (PubMed:24813849). Only mice lacking Ripk1, Ripk3 and Casp8 survive past weaning and rescue lethality caused by the absence of Ripk1 (PubMed:24813849, PubMed:24813850). {ECO:0000269|PubMed:24813849, ECO:0000269|PubMed:24813850, ECO:0000269|PubMed:9729047}. |