| 12661 | P70232 | NCHL1_MOUSE | Neural cell adhesion molecule L1-like protein (Cell adhesion molecule with homology to L1CAM) (Chl1-like protein) (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein] | DISRUPTION PHENOTYPE | Mice exhibit misguided axonal projections and aberrant axonal connectivity. They show alterations of hippocampal fiber organization and olfactory axon projections. Their exploratory behavior in novel environments is altered suggesting deficits in information processing and in attention. They also display signs of decreased stress and are more sociable and less aggressive. Heterozygous mice exhibit half levels of CHL1 expression in the hippocampus compared to their wild-type littermates, reflecting a gene dosage effect. {ECO:0000269|PubMed:12391163, ECO:0000269|PubMed:12812975, ECO:0000269|PubMed:14659567, ECO:0000269|PubMed:16623841}. |