Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:12704
  • Symbol:Cit
  • Description:citron
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Gene ID Entry Entry Name Protein Name Type Information
12704 P49025 CTRO_MOUSE Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Rho-interacting, serine/threonine-protein kinase 21) DISRUPTION PHENOTYPE Death before reaching adulthood, probably due to lethal epilepsy. Mice display severe defects in the olfactory bulbs, the hippocampus, and the cerebellum. These defects appear to result from impaired cytokinesis followed by the induction of apoptosis in specific neuroblast populations. {ECO:0000269|PubMed:11086988}.