| 12772 | P51683 | CCR2_MOUSE | C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC receptor) (MCP-1 receptor) (CD antigen CD192) | DISRUPTION PHENOTYPE | Following a stab wound brain injury, mice show reduced extracellular matrix deposition at the injured gray matter and reduced astroglial scar in the cerebral cortex (PubMed:29632244). The injury site shows an absence of invading monocytes, significantly increased astrocyte proliferation and a decrease in extracellular matrix synthesizing enzymes (PubMed:29632244). Following traumatic brain injury, mice exhibit markedly reduced early macrophage infiltration, improved locomotor activity, improved spatial learning and memory retention and increased neuronal density in the CA1-CA3 regions of the hippocampus (PubMed:24806994). Mice show impaired thymic emigration with a concomitant accumulation of mature thymocytes in the thymus (PubMed:29930553). {ECO:0000269|PubMed:24806994, ECO:0000269|PubMed:29632244, ECO:0000269|PubMed:29930553}. |