| 12801 | P47746 | CNR1_MOUSE | Cannabinoid receptor 1 (CB-R) (CB1) (Brain-type cannabinoid receptor) | DISRUPTION PHENOTYPE | No visible phenotype, although mutant mice present a mild impairment in the adaptation to new environment. Mutant mice do not respond to cannabinoids, such as anandamide. The acute effects of opiates are not affected, but the reinforcing properties of morphine and the severity of the withdrawal syndrome are strongly reduced (PubMed:9888857). On high-fat diet, mutant mice remain lean, their metabolic and hormonal profile are unchanged, and they do not develop fatty liver, despite having caloric intake similar to that of wild-type mice (PubMed:15864349). {ECO:0000269|PubMed:15864349, ECO:0000269|PubMed:9888857}. |