| 13363 | Q61488 | DHH_MOUSE | Desert hedgehog protein (DHH) (EC 3.1.-.-) (HHG-3) [Cleaved into: Desert hedgehog protein N-product] | DISRUPTION PHENOTYPE | Female mice homozygous for the Dhh gene are fully viable and fertile, whereas male mice are viable but infertile, owing to a complete absence of mature sperm (PubMed:8805249). Male mice exhibit a dramatic reduction in testicular growth (PubMed:8805249). The severity of the phenotype varies depending upon the genetic background of the mice (PubMed:8805249). The majority of the Dhh-null males are pseudohermaphrodites with a blind vaginal opening and evidence of teats. These mice show anastomotic seminiferous tubules, pertitubular cell abnormalities, and absence of adult-type Leydig cells (PubMed:11090455). {ECO:0000269|PubMed:11090455, ECO:0000269|PubMed:8805249}. |