Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:13508
  • Symbol:Dscam
  • Description:DS cell adhesion molecule
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Gene ID Entry Entry Name Protein Name Type Information
13508 Q9ERC8 DSCAM_MOUSE Cell adhesion molecule DSCAM (Down syndrome cell adhesion molecule homolog) DISRUPTION PHENOTYPE The ganglion cell layer and developing inner plexiform layer in the retina are disorganised at postnatal day 4 (P4). This desorganisation persisted into adulthood in amacrine and ganglions cells. Amacrine and ganglion cell populations show fasciculated dendrites that self-crossed and their cell bodies are randomly distributed or pulled into clumps. {ECO:0000269|PubMed:18216855, ECO:0000269|PubMed:19945391}.